PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8807181-1 1996 PURPOSE: The bradycardia produced by neostigmine and edrophonium was examined according to its relation to cholinesterase inhibition and to its sensitivity to block by muscarinic receptor antagonists. Edrophonium 53-64 butyrylcholinesterase Felis catus 107-121 8807181-12 1996 Edrophonium produced dose-dependent decreases in cholinesterase activity and heart rate, which were highly correlated (correlation coefficient r = 0.99, P < 0.0001). Edrophonium 0-11 butyrylcholinesterase Felis catus 49-63 8807181-13 1996 The ED50 of the reduction in heart rate (0.9 +/- 0.18 mg.kg-1) and cholinesterase activity (0.89 +/- 0.12 mg.kg-1) produced by edrophonium were similar. Edrophonium 127-138 butyrylcholinesterase Felis catus 67-81 8807181-14 1996 Moreover, the reduction in heart rate and cholinesterase activity produced by edrophonium reached a plateau at the same dose (6.4 mg.kg-1). Edrophonium 78-89 butyrylcholinesterase Felis catus 42-56