PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). N-acetylaspartate 76-93 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). N-acetylaspartate 104-107 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). N-acetylaspartate 236-239 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-5 2010 Whereas presymptomatic MAPT mutation carriers had elevated mI/Cr and decreased NAA/mI (p < 0.001), NAA/Cr levels and hippocampal volumes were not different from controls. N-acetylaspartate 79-82 regulator of microtubule dynamics 1 Homo sapiens 23-27 20805522-8 2010 CONCLUSION: (1)H MRS metabolite abnormalities characterized by an elevated mI/Cr and decreased NAA/mI are present several years before the onset of symptoms in MAPT mutation carriers. N-acetylaspartate 95-98 regulator of microtubule dynamics 1 Homo sapiens 160-164