PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21509595-2 2012 The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA) levels. N-acetylaspartate 135-153 brain derived neurotrophic factor Homo sapiens 78-82 23253771-0 2013 Age-modulated association between prefrontal NAA and the BDNF gene. N-acetylaspartate 45-48 brain derived neurotrophic factor Homo sapiens 57-61 23253771-3 2013 However, few studies have explored the relationship between BDNF polymorphisms and NAA levels directly. N-acetylaspartate 83-86 brain derived neurotrophic factor Homo sapiens 60-64 23253771-4 2013 Here, we present data from a single-voxel proton magnetic resonance spectroscopy study of 64 individuals and explore the relationship between BDNF polymorphisms and prefrontal NAA level. N-acetylaspartate 176-179 brain derived neurotrophic factor Homo sapiens 142-146 23253771-5 2013 Our results indicate an association between a single nucleotide polymorphism (SNP) within BDNF, known as rs1519480, and reduced NAA level (p = 0.023). N-acetylaspartate 128-131 brain derived neurotrophic factor Homo sapiens 90-94 23253771-10 2013 The rs1519480 SNP influences BDNF mRNA expression and has an impact on prefrontal NAA level over time. N-acetylaspartate 82-85 brain derived neurotrophic factor Homo sapiens 29-33 21509595-2 2012 The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA) levels. N-acetylaspartate 155-158 brain derived neurotrophic factor Homo sapiens 78-82 18707679-0 2008 Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla. N-acetylaspartate 95-113 brain derived neurotrophic factor Homo sapiens 14-47 19683059-0 2010 Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex. N-acetylaspartate 54-71 brain derived neurotrophic factor Homo sapiens 16-20 19683059-2 2010 We previously found that BDNF serum concentration was predicted by the concentration of NAA in the ACC, indicating that neuronal integrity and vitality of a cortical region like the ACC, as reflected by a high concentration of NAA, might be related to high concentrations of BDNF in serum. N-acetylaspartate 88-91 brain derived neurotrophic factor Homo sapiens 25-29 19683059-2 2010 We previously found that BDNF serum concentration was predicted by the concentration of NAA in the ACC, indicating that neuronal integrity and vitality of a cortical region like the ACC, as reflected by a high concentration of NAA, might be related to high concentrations of BDNF in serum. N-acetylaspartate 227-230 brain derived neurotrophic factor Homo sapiens 25-29 21071619-0 2011 Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes. N-acetylaspartate 45-62 brain derived neurotrophic factor Homo sapiens 126-130 21071619-0 2011 Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes. N-acetylaspartate 64-67 brain derived neurotrophic factor Homo sapiens 126-130 21071619-4 2011 Training-induced changes in NAA were, however, absent in carriers of the Met substitution in the brain-derived neurotrophic factor (BDNF) gene, which is known to reduce activity-dependent secretion of BDNF. N-acetylaspartate 28-31 brain derived neurotrophic factor Homo sapiens 97-130 21071619-4 2011 Training-induced changes in NAA were, however, absent in carriers of the Met substitution in the brain-derived neurotrophic factor (BDNF) gene, which is known to reduce activity-dependent secretion of BDNF. N-acetylaspartate 28-31 brain derived neurotrophic factor Homo sapiens 132-136 21071619-4 2011 Training-induced changes in NAA were, however, absent in carriers of the Met substitution in the brain-derived neurotrophic factor (BDNF) gene, which is known to reduce activity-dependent secretion of BDNF. N-acetylaspartate 28-31 brain derived neurotrophic factor Homo sapiens 201-205 21071619-5 2011 Among BDNF Val homozygotes, increases in NAA were strongly related to the degree of practice-related improvement in navigation performance and normalized to pretraining levels 4 months after the last training session. N-acetylaspartate 41-44 brain derived neurotrophic factor Homo sapiens 6-10 18707679-1 2008 BACKGROUND: This study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 (val66met) polymorphism on measures of N-acetyl-aspartate (NAA) containing compounds in healthy subjects. N-acetylaspartate 236-254 brain derived neurotrophic factor Homo sapiens 87-120 18707679-1 2008 BACKGROUND: This study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 (val66met) polymorphism on measures of N-acetyl-aspartate (NAA) containing compounds in healthy subjects. N-acetylaspartate 236-254 brain derived neurotrophic factor Homo sapiens 122-126 18707679-1 2008 BACKGROUND: This study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 (val66met) polymorphism on measures of N-acetyl-aspartate (NAA) containing compounds in healthy subjects. N-acetylaspartate 256-259 brain derived neurotrophic factor Homo sapiens 87-120 18707679-1 2008 BACKGROUND: This study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 (val66met) polymorphism on measures of N-acetyl-aspartate (NAA) containing compounds in healthy subjects. N-acetylaspartate 256-259 brain derived neurotrophic factor Homo sapiens 122-126 18707679-6 2008 CONCLUSIONS: We confirmed the association between the met-BDNF variant and reduced levels of hippocampal NAA found with a similar technique at 1.5T. N-acetylaspartate 105-108 brain derived neurotrophic factor Homo sapiens 58-62 17560556-2 2007 In the present study we hypothesized that serum BDNF concentration is associated with in vivo level of cerebral N-acetylaspartate (NAA), a well established marker of neuronal integrity. N-acetylaspartate 112-129 brain derived neurotrophic factor Homo sapiens 48-52 17560556-2 2007 In the present study we hypothesized that serum BDNF concentration is associated with in vivo level of cerebral N-acetylaspartate (NAA), a well established marker of neuronal integrity. N-acetylaspartate 131-134 brain derived neurotrophic factor Homo sapiens 48-52 17560556-5 2007 RESULTS: The BDNF serum concentrations were positively associated with the concentrations of NAA (T = 2.193, p = .037) and total choline (T = 1.997, p = .055; trend) but not total creatine or glutamate in the ACC. N-acetylaspartate 93-96 brain derived neurotrophic factor Homo sapiens 13-17 17560556-7 2007 CONCLUSIONS: The preliminary data might indicate that BDNF serum concentration reflects some aspects of neuronal plasticity as indicated by its association with NAA level in the cerebral cortex. N-acetylaspartate 161-164 brain derived neurotrophic factor Homo sapiens 54-58