PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30974114-2	2019	In this study, we demonstrated that CXCR6-CXCL16 axis promotes DTX resistance and acts as a counter-defense mechanism.	Digitoxigenin	63-66	C-X-C motif chemokine receptor 6	Homo sapiens	36-41	
30974114-5	2019	Furthermore, ADAM-10-mediated release of CXCL16 hyper-activated CXCR6 signaling in response to DTX.	Digitoxigenin	95-98	C-X-C motif chemokine receptor 6	Homo sapiens	64-69	
30974114-6	2019	Activation of CXCR6 resulted in increased GSK-3beta, NF-kappaB, ERK1/2 phosphorylation, and survivin expression, which reduce DTX response.	Digitoxigenin	126-129	C-X-C motif chemokine receptor 6	Homo sapiens	14-19	
30974114-7	2019	Finally, treatment of PCa cells with anti-CXCR6 monoclonal antibody synergistically or additively induced cell death with ~1.5-4.5 fold reduction in the effective concentration of DTX.	Digitoxigenin	180-183	C-X-C motif chemokine receptor 6	Homo sapiens	42-47	
30974114-8	2019	In sum, our data imply that co-targeting of CXCR6 would lead to therapeutic enhancement of DTX, leading to better clinical outcomes for PCa patients.	Digitoxigenin	91-94	C-X-C motif chemokine receptor 6	Homo sapiens	44-49	
30974114-3	2019	After CXCR6 activation, cell death in response to DTX was inhibited, and blocking of CXCR6 potentiated DTX cytotoxicity.	Digitoxigenin	50-53	C-X-C motif chemokine receptor 6	Homo sapiens	6-11	
30974114-3	2019	After CXCR6 activation, cell death in response to DTX was inhibited, and blocking of CXCR6 potentiated DTX cytotoxicity.	Digitoxigenin	103-106	C-X-C motif chemokine receptor 6	Homo sapiens	85-90	
30974114-4	2019	Moreover, in response to DTX, PCa cells expressed higher CXCR6, CXCL16, and ADAM-10.	Digitoxigenin	25-28	C-X-C motif chemokine receptor 6	Homo sapiens	57-62