PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33615694-2	2021	The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base excision repair pathway for active DNA demethylation and is required for the prevention of DNA hypermethylation at thousands of genomic regions in Arabidopsis.	5-Methylcytosine	4-20	demeter-like 1	Arabidopsis thaliana	43-47	
18493721-2	2008	Genetic and biochemical studies have revealed that the Arabidopsis DNA glycosylase domain-containing proteins ROS1 (REPRESSOR OF SILENCING 1) and DME (DEMETER) initiate erasure of 5-methylcytosine through a base excision repair process.	5-Methylcytosine	180-196	demeter-like 1	Arabidopsis thaliana	110-114	
18493721-2	2008	Genetic and biochemical studies have revealed that the Arabidopsis DNA glycosylase domain-containing proteins ROS1 (REPRESSOR OF SILENCING 1) and DME (DEMETER) initiate erasure of 5-methylcytosine through a base excision repair process.	5-Methylcytosine	180-196	demeter-like 1	Arabidopsis thaliana	116-140	
16864782-5	2006	Our data suggest that the DNA glycosylase activity of ROS1 removes 5-methylcytosine from the DNA backbone and then its lyase activity cleaves the DNA backbone at the site of 5-methylcytosine removal by successive beta- and delta-elimination reactions.	5-Methylcytosine	67-83	demeter-like 1	Arabidopsis thaliana	54-58	
16864782-5	2006	Our data suggest that the DNA glycosylase activity of ROS1 removes 5-methylcytosine from the DNA backbone and then its lyase activity cleaves the DNA backbone at the site of 5-methylcytosine removal by successive beta- and delta-elimination reactions.	5-Methylcytosine	174-190	demeter-like 1	Arabidopsis thaliana	54-58	
16624880-6	2006	Here we show that DME and ROS1 catalyze the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism.	5-Methylcytosine	55-71	demeter-like 1	Arabidopsis thaliana	26-30	
16624880-6	2006	Here we show that DME and ROS1 catalyze the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism.	5-Methylcytosine	73-78	demeter-like 1	Arabidopsis thaliana	26-30	
16624880-8	2006	DME and ROS1 show a preference for 5-meC over thymine in the symmetric dinucleotide CpG context, where most plant DNA methylation occurs.	5-Methylcytosine	35-40	demeter-like 1	Arabidopsis thaliana	8-12	
16624880-10	2006	These findings suggest that a function of ROS1 and DME is to initiate erasure of 5-meC through a base excision repair process and provide strong biochemical evidence for the existence of an active DNA demethylation pathway in plants.	5-Methylcytosine	81-86	demeter-like 1	Arabidopsis thaliana	42-46	
32927102-1	2020	The 5-methylcytosine DNA glycosylase/lyase REPRESSOR OF SILENCING 1 (ROS1)-mediated active DNA demethylation is critical for shaping the genomic DNA methylation landscape in Arabidopsis.	5-Methylcytosine	4-20	demeter-like 1	Arabidopsis thaliana	69-73	
30692220-5	2019	In Arabidopsis (Arabidopsis thaliana), active DNA demethylation depends on the activity of REPRESSOR OF SILENCING 1 (ROS1), which directly excises 5-methylcytosine from DNA.	5-Methylcytosine	147-163	demeter-like 1	Arabidopsis thaliana	91-115	
30692220-5	2019	In Arabidopsis (Arabidopsis thaliana), active DNA demethylation depends on the activity of REPRESSOR OF SILENCING 1 (ROS1), which directly excises 5-methylcytosine from DNA.	5-Methylcytosine	147-163	demeter-like 1	Arabidopsis thaliana	117-121	
27797352-1	2016	The Arabidopsis ROS1/DEMETER family of 5-methylcytosine (5mC) DNA glycosylases are the first genetically characterized DNA demethylases in eukaryotes.	5-Methylcytosine	39-55	demeter-like 1	Arabidopsis thaliana	16-20	
27797352-1	2016	The Arabidopsis ROS1/DEMETER family of 5-methylcytosine (5mC) DNA glycosylases are the first genetically characterized DNA demethylases in eukaryotes.	5-Methylcytosine	57-60	demeter-like 1	Arabidopsis thaliana	16-20	
24678721-5	2014	Although the related Repressor of Silencing 1 (ROS1) enzyme has been characterized, the molecular basis for 5mC recognition by DME has not been investigated.	5-Methylcytosine	108-111	demeter-like 1	Arabidopsis thaliana	21-45	
24678721-9	2014	Our results indicate that the 5mC binding pocket is composed of residues from discrete domains and is responsible for discrimination against 5mC derivatives, and suggest that DME, ROS1, and DML3 utilize subtly different mechanisms to probe the DNA duplex for cytosine modifications.	5-Methylcytosine	30-33	demeter-like 1	Arabidopsis thaliana	180-184	
23316050-3	2013	ROS1 and its homologs remove 5-methylcytosine and incise the sugar backbone at the abasic site, thus initiating a base excision repair pathway that finally inserts an unmethylated cytosine.	5-Methylcytosine	29-45	demeter-like 1	Arabidopsis thaliana	0-4