PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12490309-3 2003 The results revealed that I3C significantly reversed the over-expression of P-gp in vinca-alkaloid induced drug resistance as evident by Western blotting using monoclonal antibody (clone JSB1). Alkaloids 90-98 ATP binding cassette subfamily B member 1 Homo sapiens 76-80 11396162-11 2001 It is concluded that steroidal alkaloids of plant origin act as inhibitors of P-gp-mediated drug transport and multidrug resistance and therefore may serve as chemosensitizers in combination chemotherapy with conventional cytotoxic drugs for treating multidrug resistant cancer. Alkaloids 31-40 ATP binding cassette subfamily B member 1 Homo sapiens 78-82 32816867-7 2020 P-gp modulatory effects have been previously demonstrated using selected TCM, including the flavonoids, alkaloids, terpenoids, coumarins, and quinonoids compounds, and some Chinese medicine extracts. Alkaloids 104-113 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 9044851-1 1997 P-glycoprotein expression in lymphoid malignancies has the potential to compromise the efficacy of many therapeutic regimens using anthracyclines, glucocorticoids, and Vinca alkaloids. Alkaloids 174-183 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 1358068-0 1992 P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site. Alkaloids 118-126 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 1681887-1 1991 Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells. Alkaloids 63-72 ATP binding cassette subfamily B member 1 Homo sapiens 126-140 1681887-1 1991 Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells. Alkaloids 63-72 ATP binding cassette subfamily B member 1 Homo sapiens 142-145 33363626-5 2020 Among newer therapeutic approaches, the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer therapies. Alkaloids 78-87 ATP binding cassette subfamily B member 1 Homo sapiens 100-104 23999162-0 2013 Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells. Alkaloids 80-89 ATP binding cassette subfamily B member 1 Homo sapiens 124-138 26352530-13 2015 Among the four alkaloids, the permeability of BER was markedly higher than the others, and P-gp efflux had a significant effect on the absorption of those alkaloids. Alkaloids 15-24 ATP binding cassette subfamily B member 1 Homo sapiens 91-95 26352530-13 2015 Among the four alkaloids, the permeability of BER was markedly higher than the others, and P-gp efflux had a significant effect on the absorption of those alkaloids. Alkaloids 155-164 ATP binding cassette subfamily B member 1 Homo sapiens 91-95 24983126-1 2014 OBJECTIVE: Colchicine, a plant-derived alkaloid, is a known substrate for P-glycoprotein (Pgp), which confers multidrug resistance (MDR) to cancer cells and tumors, through enhanced efflux of chemotherapeutic drugs. Alkaloids 39-47 ATP binding cassette subfamily B member 1 Homo sapiens 74-88 24983126-1 2014 OBJECTIVE: Colchicine, a plant-derived alkaloid, is a known substrate for P-glycoprotein (Pgp), which confers multidrug resistance (MDR) to cancer cells and tumors, through enhanced efflux of chemotherapeutic drugs. Alkaloids 39-47 ATP binding cassette subfamily B member 1 Homo sapiens 90-93 24405813-3 2014 Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand-protein interactions and design analogues with increased affinity to Pgp. Alkaloids 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 68-71 24405813-3 2014 Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand-protein interactions and design analogues with increased affinity to Pgp. Alkaloids 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 173-176 29498663-2 2018 We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. Alkaloids 47-56 ATP binding cassette subfamily B member 1 Homo sapiens 236-250 29498663-2 2018 We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. Alkaloids 47-56 ATP binding cassette subfamily B member 1 Homo sapiens 252-256 29498663-4 2018 Furthermore, rhodamine (Rho) 123 and calcein-AM were used to detect the effects of alkaloids on the activity of P-gp. Alkaloids 83-92 ATP binding cassette subfamily B member 1 Homo sapiens 112-116 27399665-5 2016 This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships. Alkaloids 96-105 ATP binding cassette subfamily B member 1 Homo sapiens 194-198 23238299-8 2013 Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA. Alkaloids 41-49 ATP binding cassette subfamily B member 1 Homo sapiens 154-158 22411726-5 2012 Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. Alkaloids 140-149 ATP binding cassette subfamily B member 1 Homo sapiens 30-34 22411726-7 2012 These observations indicated that the three alkaloids may not only be P-gp inhibitors but also its substrates; they interact with each other and can potentially enhance their own bioavailability when taken concomitantly. Alkaloids 44-53 ATP binding cassette subfamily B member 1 Homo sapiens 70-74 22411726-5 2012 Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. Alkaloids 140-149 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 21262330-2 2011 The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied. Alkaloids 19-28 ATP binding cassette subfamily B member 1 Homo sapiens 148-152 16783693-0 2006 Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. Alkaloids 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 58-72 19368123-2 2009 The tested alkaloids were evaluated for their multidrug resistance (MDR)-reversing activity on human MDR1-gene-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay. Alkaloids 11-20 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Alkaloids 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 166-170 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Alkaloids 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 187-192 16783693-0 2006 Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. Alkaloids 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 74-78 16783693-0 2006 Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. Alkaloids 33-41 ATP binding cassette subfamily B member 1 Homo sapiens 79-84