PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23931437-3 2013 Naturally occurring alkaloids are an important source of AChE inhibitors. Alkaloids 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Alkaloids 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 24606395-0 2014 Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. Alkaloids 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. Alkaloids 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24236981-7 2013 Following this view, an increasing interest in achieving more potent and effective analogues makes alkaloids good chemical templates for the development of new cholinesterase inhibitors. Alkaloids 99-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-174 22734711-2 2013 In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study. Alkaloids 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 22734711-2 2013 In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study. Alkaloids 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 18069241-2 2007 Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively]. Alkaloids 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 19101888-0 2009 Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala. Alkaloids 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19101888-2 2009 The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Alkaloids 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 19101888-2 2009 The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Alkaloids 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20079560-0 2010 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Alkaloids 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 19555175-9 2009 The MD results clearly provide an explanation for the binding pattern of bulky steroidal alkaloids at the active site of AChE. Alkaloids 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 17188496-0 2007 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. Alkaloids 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 17653364-1 2007 A great number of natural products, especially alkaloids, which exhibit a range of biological activities including acetylcholinesterase inhibition and antineoplastic, cardiovascular and immunostimulatory activities, have been isolated from the plants of the Amaryllidaceae family. Alkaloids 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 1206408-0 1975 Inhibition of acetylcholinesterase by bicuculline and related alkaloids. Alkaloids 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 16881015-4 2006 The effects of the five alkaloids on human red blood cell (RBC) acetylcholinesterase (AChE) and human plasma butyrylcholinesterase (BChE) were further studied, and their IC (50) values for human RBC AChE were 6.4 +/- 0.003 microM, 16.9 +/- 0.018 microM, 5.7 +/- 0.004 microM, 6.5 +/- 0.013 microM and 7.7 +/- 0.001 microM, respectively, and the IC50 values for human plasma BChE were 12.5 +/- 0.026 microM, 2.1 +/- 0.005 microM, 5.2 +/- 0.002 microM, 7.3 +/- 0.005 microM and 0.7 +/- 0.001 microM, respectively. Alkaloids 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11966199-0 2002 [Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood]. Alkaloids 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-82 11140610-4 2000 In conclusion, the value of the bimolecular rate constant for selected AChE inhibitors (structural changes that have been hypothesised or natural alkaloids of unknown activity) which possess similar size and rigidity, can be obtained. Alkaloids 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34664067-8 2021 UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine. Alkaloids 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 35385268-9 2022 The mechanism of the different effects of alkaloids on inhibiting acetylcholinesterase activity was explored via molecular docking and kinetic simulation. Alkaloids 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 296-316 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-322 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 296-316 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-322 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Alkaloids 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Alkaloids 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 30990078-0 2021 Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC-MS combined with multivariate analyses and in silico studies. Alkaloids 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 33439402-5 2021 The binding free energy calculation and ligand-protein binding pattern suggested that both alkaloids could interact with AChE very well. Alkaloids 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30990078-6 2021 Furthermore, the molecular docking was performed to illustrate binding orientations of the top scoring alkaloids in the active site of human acetylcholinesterase. Alkaloids 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 33652925-5 2021 Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. Alkaloids 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-81 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 33020380-3 2020 The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE). Alkaloids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-259 33020380-3 2020 The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE). Alkaloids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 33020380-8 2020 The combination of these techniques confirmed the presence of the alkaloids and enabled the development of a modern method for the fractionation and isolation of the compounds with strong anti-AChE activity. Alkaloids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 31220673-11 2019 The molecular modeling studies with AChE and BChE have shown that both alkaloids were tightly packed inside the active site gorge (site 1) via multiple pi-pi and cation-pi interactions. Alkaloids 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 32991579-4 2020 Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking. Alkaloids 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32155491-4 2020 Alkaloid isolation from root extract of Zanthoxylum rigidum was carried out using multi-step chromatography and TLC-bioautography against acetylcholinesterase (AChE) giving eight purified isoquinoline alkaloids. Alkaloids 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 30959739-6 2019 Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate. Alkaloids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-76 30959739-6 2019 Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate. Alkaloids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 30178271-10 2018 Several new polymeric alkaloids were found to lack cytotoxicity against a number of human cancer cell lines, although two of them showed moderate aphicidal activity and one exhibited weak to moderate acetylcholinesterase inhibition. Alkaloids 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 30405413-4 2018 However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs. Alkaloids 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 28497342-0 2017 Exploration of the Acetylcholinesterase Inhibitory Activity of Some Alkaloids from Amaryllidaceae Family by Molecular Docking In Silico. Alkaloids 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28497342-6 2017 In this context, the purpose of this study was to apply the docking molecular in silico analysis aiming to examine the recombinant human AChE enzyme (rhAChE) inhibitory activity displayed by different alkaloids from Amaryllidaceae family. Alkaloids 201-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141