PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31011359-4	2019	The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta.	Alkaloids	77-86	tumor necrosis factor	Rattus norvegicus	153-162	
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	265-274	
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	123-150	
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	152-161	
11218731-3	2001	To explore further the mechanism of the suppression for inflammation, we studied the effect of the alkaloids on macrophage tumor necrosis factor (TNF-alpha) production in vitro, since TNF-alpha is recognized as a pivotal cytokine to regulate inflammation.	Alkaloids	99-108	tumor necrosis factor	Rattus norvegicus	146-155	
11218731-9	2001	From these results, it was concluded that these alkaloids exert inhibitory effects not only on neutrophil apoptosis-inducing protein, calprotectin, but also on macrophage TNF-alpha production.	Alkaloids	48-57	tumor necrosis factor	Rattus norvegicus	171-180