PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29714135-0 2019 Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents? Alkaloids 8-17 insulin Homo sapiens 34-41 29714135-4 2019 PURPOSE: To discuss current concepts on the anti-diabetic impact of certain alkaloids, with special reference to their molecular targets throughout the insulin-signaling pathway. Alkaloids 76-85 insulin Homo sapiens 152-159 29714135-5 2019 METHODOLOGY: Upon in-depth search in the SCOPUS and PUBMED databases, the literature on alkaloids with insulin secretion/sensitization properties was critically reviewed. Alkaloids 88-97 insulin Homo sapiens 103-110 29714135-9 2019 DISCUSSION: Growing evidence suggests the ability of specific alkaloids to intervene in the insulin-signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance and improve disease complications, in-vitro and in-vivo. Alkaloids 62-71 insulin Homo sapiens 92-99 29714135-9 2019 DISCUSSION: Growing evidence suggests the ability of specific alkaloids to intervene in the insulin-signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance and improve disease complications, in-vitro and in-vivo. Alkaloids 62-71 insulin Homo sapiens 168-175 28257977-8 2017 Hypoglycemic effects of fruits and vegetables may be due to their inducing nature on pancreatic beta-cells for insulin secretion, or bioactive compounds such as flavonoids, alkaloids and anthocyanins, which act as insulin-like molecules or insulin secretagogues. Alkaloids 173-182 insulin Homo sapiens 214-221 35001637-7 2022 Many kinds of natural products promote white adipose tissue browning, such as alkaloids, flavonoids, terpenoids, and long-chain fatty acids, which can also ameliorate metabolic disorders including obesity, insulin resistance and diabetes. Alkaloids 78-87 insulin Homo sapiens 206-213 33823775-8 2021 Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control. Alkaloids 93-102 insulin Homo sapiens 197-204