PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28801761-5 2017 The alkaloid was able to inhibit the peritonitis induced by carrageenan, decreasing mainly the migration of polymorphonuclear cells, without altering the mononuclear cell number, and reduced the levels of TNF-alpha and IL-1beta in the peritoneum. Alkaloids 4-12 interleukin 1 beta Homo sapiens 219-227 8824940-4 1995 Of note was that these two alkaloids appeared to inhibit IL-1 beta production more effectively than IL-1 alpha production. Alkaloids 27-36 interleukin 1 beta Homo sapiens 57-66 8824940-5 1995 When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively. Alkaloids 81-90 interleukin 1 beta Homo sapiens 126-135 8824940-5 1995 When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively. Alkaloids 211-220 interleukin 1 beta Homo sapiens 126-135 22592163-3 2012 This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. Alkaloids 43-52 interleukin 1 beta Homo sapiens 232-240