PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20851588-10	2011	CYP2C19 was inhibited by 15/36 alkaloids at least moderate potently, whereas CYP1A2, CYP2B6, CYP2C8, and CYP2C9 were inhibited to a lesser degree.	Alkaloids	31-40	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7	
26400396-5	2015	The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19.	Alkaloids	23-32	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	139-146	
26400396-5	2015	The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19.	Alkaloids	79-88	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	139-146	
21908684-2	2011	The recently reported fluorometric CYP2C19 progress curve analysis approach was applied first to determine whether these alkaloids demonstrate time-dependent inhibition.	Alkaloids	121-130	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	35-42	
21908684-5	2011	CYP2C19 activity was not significantly restored by dialysis when it had been inactivated by the alkaloids in the presence of a NADPH-regenerating system, and a metabolic-intermediate complex-associated increase in absorbance at approximately 455 nm was observed.	Alkaloids	96-105	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7	
21908684-6	2011	In conclusion, the CYP2C19 progress curve analysis method revealed time-dependent inhibition by these alkaloids, and additional experiments confirmed its quasi-irreversible nature.	Alkaloids	102-111	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	19-26	
21908684-8	2011	The alkaloids bulbocapnine, canadine, and protopine, present in herbal medicines, are new mechanism-based inactivators and the first MDP compounds exhibiting quasi-irreversible inactivation of CYP2C19.	Alkaloids	4-13	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	193-200