PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20851588-10 2011 CYP2C19 was inhibited by 15/36 alkaloids at least moderate potently, whereas CYP1A2, CYP2B6, CYP2C8, and CYP2C9 were inhibited to a lesser degree. Alkaloids 31-40 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 26400396-5 2015 The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19. Alkaloids 23-32 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 139-146 26400396-5 2015 The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19. Alkaloids 79-88 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 139-146 21908684-2 2011 The recently reported fluorometric CYP2C19 progress curve analysis approach was applied first to determine whether these alkaloids demonstrate time-dependent inhibition. Alkaloids 121-130 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 35-42 21908684-5 2011 CYP2C19 activity was not significantly restored by dialysis when it had been inactivated by the alkaloids in the presence of a NADPH-regenerating system, and a metabolic-intermediate complex-associated increase in absorbance at approximately 455 nm was observed. Alkaloids 96-105 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 21908684-6 2011 In conclusion, the CYP2C19 progress curve analysis method revealed time-dependent inhibition by these alkaloids, and additional experiments confirmed its quasi-irreversible nature. Alkaloids 102-111 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 19-26 21908684-8 2011 The alkaloids bulbocapnine, canadine, and protopine, present in herbal medicines, are new mechanism-based inactivators and the first MDP compounds exhibiting quasi-irreversible inactivation of CYP2C19. Alkaloids 4-13 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 193-200