PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9651189-0 1998 Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells. monocrotaline pyrrole 67-88 cyclin dependent kinase 1 Bos taurus 52-56 9651189-7 1998 Western blot examination revealed that by 24 h of MCTP exposure, the phosphorylation state of cdc2 was consistent with the inactive form of the kinase (confirmed by biochemical assay); this alteration persisted through at least 96 h of exposure. monocrotaline pyrrole 50-54 cyclin dependent kinase 1 Bos taurus 94-98 9651189-8 1998 We conclude that MCTP induces a progressive irreversible endothelial cell dysfunction leading to inactivation of cdc2 kinase and irreversible cell-cycle arrest at the G2 checkpoint. monocrotaline pyrrole 17-21 cyclin dependent kinase 1 Bos taurus 113-117