PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33318128-7 2021 The conformations of NKA are virtually identical in all complexes with and without CTSs, showing that CTSs bind to a preformed cavity in NKA. Cardiac Glycosides 83-87 tachykinin precursor 1 Homo sapiens 21-24 33644859-1 2022 Na+ /K+ ATPase (NKA), a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids (CTS) such as ouabain. Cardiac Glycosides 174-177 tachykinin precursor 1 Homo sapiens 0-14 33644859-1 2022 Na+ /K+ ATPase (NKA), a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids (CTS) such as ouabain. Cardiac Glycosides 174-177 tachykinin precursor 1 Homo sapiens 16-19 15970511-1 2005 There is growing evidence that the adrenal cortex is the source of cardiotonic steroid (CS) regulators of sodium, potassium-ATPase (NKA). Cardiac Glycosides 88-90 tachykinin precursor 1 Homo sapiens 132-135 11357898-1 2001 Na,K-ATPase (NKA, Na-pump), an alphabeta heteromer, is the receptor for cardiac glycosides (CG) which exert a positive inotropic effect by inhibiting enzyme activity, decreasing the driving force for Na,Ca-exchange (NCX) and increasing cellular content and release of Ca2+ during depolarization. Cardiac Glycosides 92-94 tachykinin precursor 1 Homo sapiens 0-11 11357898-1 2001 Na,K-ATPase (NKA, Na-pump), an alphabeta heteromer, is the receptor for cardiac glycosides (CG) which exert a positive inotropic effect by inhibiting enzyme activity, decreasing the driving force for Na,Ca-exchange (NCX) and increasing cellular content and release of Ca2+ during depolarization. Cardiac Glycosides 92-94 tachykinin precursor 1 Homo sapiens 13-16 34064873-5 2021 Although the anticancer mechanism of CGs has not been fully elucidated, yet, it is thought to be connected with the second role of NKA being a receptor that can induce several cell signaling cascades and even serve as a growth factor and, thus, inhibit cancer cell proliferation at low nontoxic concentrations. Cardiac Glycosides 37-40 tachykinin precursor 1 Homo sapiens 131-134 33318128-7 2021 The conformations of NKA are virtually identical in all complexes with and without CTSs, showing that CTSs bind to a preformed cavity in NKA. Cardiac Glycosides 102-106 tachykinin precursor 1 Homo sapiens 21-24 33318128-7 2021 The conformations of NKA are virtually identical in all complexes with and without CTSs, showing that CTSs bind to a preformed cavity in NKA. Cardiac Glycosides 102-106 tachykinin precursor 1 Homo sapiens 137-140 31669257-4 2020 We compared the potency of fourteen related cardiotonic steroids (CTS) for inhibition of the cycling pig kidney NKA in two different concentrations of K+, as well as the affinity for binding to the E2P conformation of the enzyme (Mg-Pi medium) and the potency for inhibiting the E2[2K] conformation of the NKA (K+-pNPPase activity). Cardiac Glycosides 66-69 tachykinin precursor 1 Homo sapiens 112-115 29115894-1 2018 Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. Cardiac Glycosides 40-43 tachykinin precursor 1 Homo sapiens 78-89 29115894-1 2018 Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. Cardiac Glycosides 40-43 tachykinin precursor 1 Homo sapiens 91-94 30200235-4 2018 In fact, NKA ligands such as cardiotonic steroids (CTS), have been shown to signal through NKA, and consequently been implicated in mediating both adaptive and maladaptive responses to volume overload such as fibrosis and oxidative stress. Cardiac Glycosides 51-54 tachykinin precursor 1 Homo sapiens 9-12 30200235-4 2018 In fact, NKA ligands such as cardiotonic steroids (CTS), have been shown to signal through NKA, and consequently been implicated in mediating both adaptive and maladaptive responses to volume overload such as fibrosis and oxidative stress. Cardiac Glycosides 51-54 tachykinin precursor 1 Homo sapiens 91-94 30200235-5 2018 In this review we will emphasize the role the NKA plays in this "trade-off" with respect to CTS signaling and its implication in inflammation and fibrosis in target organs including the heart, kidney, and vasculature. Cardiac Glycosides 92-95 tachykinin precursor 1 Homo sapiens 46-49 26909067-2 2016 NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Cardiac Glycosides 238-241 tachykinin precursor 1 Homo sapiens 0-3 27553475-1 2017 Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Cardiac Glycosides 20-23 tachykinin precursor 1 Homo sapiens 182-185 27377465-1 2016 Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition of cardiac Na(+), K(+)-ATPase (NKA). Cardiac Glycosides 22-25 tachykinin precursor 1 Homo sapiens 137-155 27377465-1 2016 Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition of cardiac Na(+), K(+)-ATPase (NKA). Cardiac Glycosides 22-25 tachykinin precursor 1 Homo sapiens 157-160 27031987-1 2016 Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. Cardiac Glycosides 20-23 tachykinin precursor 1 Homo sapiens 40-53 27031987-1 2016 Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. Cardiac Glycosides 20-23 tachykinin precursor 1 Homo sapiens 55-58 26909067-1 2016 Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). Cardiac Glycosides 22-25 tachykinin precursor 1 Homo sapiens 87-90 28550304-1 2017 The current study explored the Na+/K+-ATPase (NKA) inhibition-independent proarrhythmic mechanisms of cardiac glycosides (CGs) which are well-known NKA inhibitors. Cardiac Glycosides 122-125 tachykinin precursor 1 Homo sapiens 148-151 26909067-1 2016 Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). Cardiac Glycosides 22-25 tachykinin precursor 1 Homo sapiens 66-85 26909067-2 2016 NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Cardiac Glycosides 238-241 tachykinin precursor 1 Homo sapiens 179-182 26491887-2 2015 Cardiac glycosides (CGs), as a family of naturally compounds, inhibited the NKA activity. Cardiac Glycosides 20-23 tachykinin precursor 1 Homo sapiens 76-79 24610665-2 2015 Cardiac glycosides (CGs) belong to NKA inhibitors and possess potent anti-cancer properties in many cancers. Cardiac Glycosides 20-23 tachykinin precursor 1 Homo sapiens 35-38