PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	48-65	fms related receptor tyrosine kinase 3	Homo sapiens	209-235	
28061447-0	2017	The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia.	Homoharringtonine	26-43	fms related receptor tyrosine kinase 3	Homo sapiens	61-65	
28061447-3	2017	In this study, we explored the inhibitory effect and mechanism of homoharringtonine (HHT) in combination with ibrutinib on FLT3-ITD mutant AML cells.	Homoharringtonine	66-83	fms related receptor tyrosine kinase 3	Homo sapiens	123-127	
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	48-65	fms related receptor tyrosine kinase 3	Homo sapiens	237-241	
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	67-70	fms related receptor tyrosine kinase 3	Homo sapiens	209-235	
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	67-70	fms related receptor tyrosine kinase 3	Homo sapiens	237-241	
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	87-112	fms related receptor tyrosine kinase 3	Homo sapiens	209-235	
27708062-2	2016	Unbiased clustering and correlation showed that homoharringtonine (HHT), also known as omacetaxine mepesuccinate, exhibited preferential antileukemia effect against AML carrying internal tandem duplication of fms-like tyrosine kinase 3 (FLT3-ITD).	Homoharringtonine	87-112	fms related receptor tyrosine kinase 3	Homo sapiens	237-241	
26884901-4	2015	To the best of our knowledge, this is the first case report about sorafenib in combination with low-dose-homoharringtonine as a salvage therapy successfully administrated and got complete remission (CR) in primary refractory FLT3-ITD-positive AML.	Homoharringtonine	105-122	fms related receptor tyrosine kinase 3	Homo sapiens	225-229	
34594375-0	2021	Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines.	Homoharringtonine	0-17	fms related receptor tyrosine kinase 3	Homo sapiens	130-134	
34594375-2	2021	This study is directed to investigate gilteritinib in combination with homoharringtonine (HHT) on FLT3-ITD-mutant AML cell lines.	Homoharringtonine	71-88	fms related receptor tyrosine kinase 3	Homo sapiens	98-102	
30975912-6	2020	Our work also highlights the particular promise of clinical application of homoharringtonine to treat human acute myeloid leukemia with FLT3 mutations, which accounts for more than 30% of total acute myeloid leukemia cases.	Homoharringtonine	75-92	fms related receptor tyrosine kinase 3	Homo sapiens	136-140	
33831397-0	2021	Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway.	Homoharringtonine	0-17	fms related receptor tyrosine kinase 3	Homo sapiens	49-53	
30975912-4	2020	Our further 5hmC-seq and RNA-seq analyses, followed by a series of validation and functional studies, suggest that FLT3 is a critical down-stream target of the homoharringtonine/SP1/TET1/5hmC signaling, and suppression of FLT3 and its downstream targets (e.g., MYC) contributes to the high sensitivity of FLT3-mutated acute myeloid leukemia cells to homoharringtonine.	Homoharringtonine	160-177	fms related receptor tyrosine kinase 3	Homo sapiens	115-119	
30975912-4	2020	Our further 5hmC-seq and RNA-seq analyses, followed by a series of validation and functional studies, suggest that FLT3 is a critical down-stream target of the homoharringtonine/SP1/TET1/5hmC signaling, and suppression of FLT3 and its downstream targets (e.g., MYC) contributes to the high sensitivity of FLT3-mutated acute myeloid leukemia cells to homoharringtonine.	Homoharringtonine	160-177	fms related receptor tyrosine kinase 3	Homo sapiens	222-226	
30975912-4	2020	Our further 5hmC-seq and RNA-seq analyses, followed by a series of validation and functional studies, suggest that FLT3 is a critical down-stream target of the homoharringtonine/SP1/TET1/5hmC signaling, and suppression of FLT3 and its downstream targets (e.g., MYC) contributes to the high sensitivity of FLT3-mutated acute myeloid leukemia cells to homoharringtonine.	Homoharringtonine	160-177	fms related receptor tyrosine kinase 3	Homo sapiens	222-226	
30975912-4	2020	Our further 5hmC-seq and RNA-seq analyses, followed by a series of validation and functional studies, suggest that FLT3 is a critical down-stream target of the homoharringtonine/SP1/TET1/5hmC signaling, and suppression of FLT3 and its downstream targets (e.g., MYC) contributes to the high sensitivity of FLT3-mutated acute myeloid leukemia cells to homoharringtonine.	Homoharringtonine	350-367	fms related receptor tyrosine kinase 3	Homo sapiens	115-119	
30975912-5	2020	Collectively, our studies uncover a previously unappreciated, DNA epigenome-related mechanism underlying the potent antileukemic effect of homoharringtonine, which involves suppression of the SP1/TET1/5hmC/FLT3/MYC signaling pathways in acute myeloid leukemia.	Homoharringtonine	139-156	fms related receptor tyrosine kinase 3	Homo sapiens	206-210