PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27890529-5 2017 Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 7-9 29643369-1 2018 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 0-20 29643369-1 2018 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 22-24 27890529-5 2017 Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 116-118 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Oxaloacetic Acid 115-127 pyruvate carboxylase Homo sapiens 0-20 27493727-7 2016 Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate. Oxaloacetic Acid 105-117 pyruvate carboxylase Homo sapiens 26-28 27493727-7 2016 Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate. Oxaloacetic Acid 221-233 pyruvate carboxylase Homo sapiens 26-28 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Oxaloacetic Acid 261-273 pyruvate carboxylase Homo sapiens 0-20 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Oxaloacetic Acid 261-273 pyruvate carboxylase Homo sapiens 22-24 27732858-2 2016 The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate. Oxaloacetic Acid 71-83 pyruvate carboxylase Homo sapiens 88-108 27732858-2 2016 The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate. Oxaloacetic Acid 71-83 pyruvate carboxylase Homo sapiens 110-112 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Oxaloacetic Acid 99-111 pyruvate carboxylase Homo sapiens 0-20 26070193-1 2015 Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes. Oxaloacetic Acid 99-111 pyruvate carboxylase Homo sapiens 22-24 28649521-1 2015 Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate. Oxaloacetic Acid 115-127 pyruvate carboxylase Homo sapiens 22-24 23098296-1 2012 Pyruvate carboxylase [EC 6.4.1.1] plays an important anaplerotic role in many species by catalyzing the carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 133-145 pyruvate carboxylase Homo sapiens 0-20 23698000-2 2013 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Oxaloacetic Acid 146-158 pyruvate carboxylase Homo sapiens 0-20 23698000-2 2013 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Oxaloacetic Acid 146-158 pyruvate carboxylase Homo sapiens 22-24 20598931-1 2010 Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism. Oxaloacetic Acid 107-119 pyruvate carboxylase Homo sapiens 0-20 20807508-1 2010 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. Oxaloacetic Acid 100-112 pyruvate carboxylase Homo sapiens 0-20 20807508-1 2010 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates. Oxaloacetic Acid 100-112 pyruvate carboxylase Homo sapiens 22-24 21958016-1 2011 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 0-20 21934355-2 2011 The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate. Oxaloacetic Acid 49-61 pyruvate carboxylase Homo sapiens 11-31 21934355-2 2011 The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate. Oxaloacetic Acid 154-166 pyruvate carboxylase Homo sapiens 11-31 20598931-1 2010 Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism. Oxaloacetic Acid 107-119 pyruvate carboxylase Homo sapiens 22-24 18297087-1 2008 Pyruvate carboxylase (PC) catalyzes the biotin-dependent production of oxaloacetate and has important roles in gluconeogenesis, lipogenesis, insulin secretion and other cellular processes. Oxaloacetic Acid 71-83 pyruvate carboxylase Homo sapiens 0-20 18686030-2 2009 PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Oxaloacetic Acid 42-54 pyruvate carboxylase Homo sapiens 0-2 18613815-1 2008 PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. Oxaloacetic Acid 140-152 pyruvate carboxylase Homo sapiens 0-2 18613815-1 2008 PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. Oxaloacetic Acid 140-152 pyruvate carboxylase Homo sapiens 4-24 5158897-11 1971 They also support the view that oxaloacetate for citrate synthesis is preferentially formed from pyruvate through pyruvate carboxylase rather than malate through malate dehydrogenase and that the mitochondrial metabolism of citrate in fat-cells is restricted. Oxaloacetic Acid 32-44 pyruvate carboxylase Homo sapiens 114-134 16505973-1 2006 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 0-20 16505973-1 2006 Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 83-95 pyruvate carboxylase Homo sapiens 22-24 16505973-3 2006 In liver and kidney, PC provides oxaloacetate for gluconeogenesis. Oxaloacetic Acid 33-45 pyruvate carboxylase Homo sapiens 21-23 8349677-9 1993 Association of citrate synthase with the malate dehydrogenase-pyruvate carboxylase binary complex does not alter activation of pyruvate carboxylase but results in citrate synthase being more reactive than free citrate synthase with oxalacetate. Oxaloacetic Acid 232-243 pyruvate carboxylase Homo sapiens 62-82 33808495-8 2021 The pyruvate carboxylase reaction that anaplerotically supplies oxaloacetate; 5. Oxaloacetic Acid 64-76 pyruvate carboxylase Homo sapiens 4-24 34931827-1 2022 Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. Oxaloacetic Acid 84-96 pyruvate carboxylase Homo sapiens 101-121 34136384-5 2021 Pyruvate carboxylase (PC) is a major anaplerotic enzyme that catalyzes the carboxylation of pyruvate to form oxaloacetate, which has been suggested to be involved in the tumorigenesis of several cancers, including PTC. Oxaloacetic Acid 109-121 pyruvate carboxylase Homo sapiens 0-20 34150393-1 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Oxaloacetic Acid 47-59 pyruvate carboxylase Homo sapiens 0-20 34150393-1 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Oxaloacetic Acid 47-59 pyruvate carboxylase Homo sapiens 22-24 3028472-0 1986 Carbon-13 and deuterium isotope effects on oxalacetate decarboxylation by pyruvate carboxylase. Oxaloacetic Acid 43-54 pyruvate carboxylase Homo sapiens 74-94 3091918-7 1986 Oxaloacetate is primarily generated by the carboxylation of pyruvate catalysed by pyruvate carboxylase. Oxaloacetic Acid 0-12 pyruvate carboxylase Homo sapiens 82-102 4354325-10 1972 In particular, pyruvate carboxylase may be present in insect flight muscle for the provision of oxaloacetate to support the large increase in activity of the tricarboxylic acid cycle which occurs when an insect takes flight. Oxaloacetic Acid 96-108 pyruvate carboxylase Homo sapiens 15-35 10229653-1 1999 Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 144-156 pyruvate carboxylase Homo sapiens 0-20 10229653-1 1999 Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. Oxaloacetic Acid 144-156 pyruvate carboxylase Homo sapiens 22-24 9585002-1 1998 Pyruvate carboxylase (PC) is a biotinylated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Oxaloacetic Acid 110-122 pyruvate carboxylase Homo sapiens 0-20 7650022-13 1995 Taken together with previous studies, the current results suggest that during glucose-induced insulin secretion there is a shuttle operating across the mitochondrial membrane in which glucose-derived pyruvate is taken up by mitochondria and carboxylated to oxaloacetate by pyruvate carboxylase. Oxaloacetic Acid 257-269 pyruvate carboxylase Homo sapiens 273-293 3814578-0 1986 Decarboxylation of oxalacetate by pyruvate carboxylase. Oxaloacetic Acid 19-30 pyruvate carboxylase Homo sapiens 34-54 3814578-1 1986 The decarboxylation of oxalacetate by pyruvate carboxylase in the absence of ADP and Pi is stimulated 400-fold by the presence of oxamate, which is an inhibitory analogue of pyruvate. Oxaloacetic Acid 23-34 pyruvate carboxylase Homo sapiens 38-58 3814578-4 1986 The pH profiles of the full reverse reaction of pyruvate carboxylase in which oxalacetate decarboxylation is coupled to ATP formation and where Pi is the variable substrate do, however, indicate that such an acid-base catalyst is involved in the other partial reaction of the enzyme in proton transfer to and from biotin. Oxaloacetic Acid 78-89 pyruvate carboxylase Homo sapiens 48-68 2859839-8 1985 It was suggested that, in coordination with pyruvate carboxylase, aspartate-4-decarboxylase is important in regulating the metabolic fate of oxaloacetate and thus plays a role in determining the efficiency of carbohydrate metabolism. Oxaloacetic Acid 141-153 pyruvate carboxylase Homo sapiens 44-64 31697914-1 2019 Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate. Oxaloacetic Acid 82-94 pyruvate carboxylase Homo sapiens 0-20 33880999-1 2021 Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism. Oxaloacetic Acid 80-92 pyruvate carboxylase Homo sapiens 0-20 33880999-1 2021 Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism. Oxaloacetic Acid 80-92 pyruvate carboxylase Homo sapiens 22-24 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Oxaloacetic Acid 114-126 pyruvate carboxylase Homo sapiens 0-20 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Oxaloacetic Acid 114-126 pyruvate carboxylase Homo sapiens 22-24 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Oxaloacetic Acid 128-131 pyruvate carboxylase Homo sapiens 0-20 33931119-1 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. Oxaloacetic Acid 128-131 pyruvate carboxylase Homo sapiens 22-24 33109566-1 2020 BACKGROUND/AIM: Pyruvate carboxylase (PC) is a major anaplerotic enzyme for generating oxaloacetate for the TCA cycle and also a key enzyme in gluconeogenesis, de novo fatty acid and amino acid synthesis in normal cells. Oxaloacetic Acid 87-99 pyruvate carboxylase Homo sapiens 16-36 31697914-1 2019 Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate. Oxaloacetic Acid 82-94 pyruvate carboxylase Homo sapiens 22-24 31180060-1 2019 Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2. Oxaloacetic Acid 50-66 pyruvate carboxylase Homo sapiens 0-20 31180060-1 2019 Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2. Oxaloacetic Acid 50-66 pyruvate carboxylase Homo sapiens 22-25 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Oxaloacetic Acid 146-158 pyruvate carboxylase Homo sapiens 0-20 30045381-1 2018 Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle. Oxaloacetic Acid 146-158 pyruvate carboxylase Homo sapiens 22-24 30005601-4 2018 Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle. Oxaloacetic Acid 68-80 pyruvate carboxylase Homo sapiens 0-20 30005601-4 2018 Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle. Oxaloacetic Acid 68-80 pyruvate carboxylase Homo sapiens 22-24