PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21764262-3 2011 Using murine J774 macrophages and human THP-1 monocytes, we show that gemifloxacin accumulates more than ciprofloxacin and even moxifloxacin. Gemifloxacin 70-82 GLI family zinc finger 2 Homo sapiens 40-45 15497755-0 2004 In vitro anti-inflammatory effects and immunomodulation by gemifloxacin in stimulated human THP-1 monocytes. Gemifloxacin 59-71 GLI family zinc finger 2 Homo sapiens 92-97 15497755-3 2004 The effects of gemifloxacin on DNA synthesis and killing of S. aureus was assessed in bacteria alone and in those bacteria phagocytosed by THP-1 monocytes over 24 h. Gemifloxacin in stimulated THP-1 monocytes over the first 30 min caused an increase in c-AMP, NO, H2O2 and TNFalpha levels and protein kinase C, NADPH oxidase, glutathione reductase, NAG and cathepsin D activities. Gemifloxacin 166-178 GLI family zinc finger 2 Homo sapiens 139-144 15497755-3 2004 The effects of gemifloxacin on DNA synthesis and killing of S. aureus was assessed in bacteria alone and in those bacteria phagocytosed by THP-1 monocytes over 24 h. Gemifloxacin in stimulated THP-1 monocytes over the first 30 min caused an increase in c-AMP, NO, H2O2 and TNFalpha levels and protein kinase C, NADPH oxidase, glutathione reductase, NAG and cathepsin D activities. Gemifloxacin 166-178 GLI family zinc finger 2 Homo sapiens 193-198 15497755-6 2004 These effects were at a higher magnitude at 24 h. Gemifloxacin initiates a phagocyticidal effect of THP-1 monocytes at an early time of 30 min which plays a role in killing bacteria but a higher magnitude of killing of bacteria occurs later by a standard static mechanism. Gemifloxacin 50-62 GLI family zinc finger 2 Homo sapiens 100-105