PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15714752-12	1995	Tyrphostin 23 inhibited [Ca2+]i induced by either thrombin or SFLLRN in all species.	Tyrphostins	0-10	coagulation factor II, thrombin	Homo sapiens	50-58	
9813145-5	1998	In the presence of tyrphostin to inhibit thrombin-induced SHP-1 tyrosine phosphorylation, SHP-1 was cleaved.	Tyrphostins	19-29	coagulation factor II, thrombin	Homo sapiens	41-49	
9069588-9	1997	Tyrphostin, pertussis toxin, or H-7 suppressed trypsin- and thrombin-induced GM-CSF gene expression.	Tyrphostins	0-10	coagulation factor II, thrombin	Homo sapiens	60-68	
8199204-5	1994	Both staurosporine and tyrphostin inhibited thrombin-stimulated tyrosine phosphorylation and PtdIns(3,4)P2 synthesis.	Tyrphostins	23-33	coagulation factor II, thrombin	Homo sapiens	44-52	
7723744-9	1995	It is concluded that elevation of intracellular Ca2+ regulates agonist-induced activation of phospholipase C and that this contributes to the inhibition of thrombin-induced formation of inositol phosphates by the tyrphostin ST271.	Tyrphostins	213-223	coagulation factor II, thrombin	Homo sapiens	156-164	
7526916-4	1994	PLD was activated in response to 0.3 U/ml thrombin, and this activation was reduced by several of the PTK inhibitors, especially genistein, methyl 2,5-dihydroxycinnamate (MDHC), ST271, and the tyrphostins A25 and A47.	Tyrphostins	193-204	coagulation factor II, thrombin	Homo sapiens	42-50	
1382425-1	1992	Protein tyrosine kinase (PTK) blockers (tyrphostins) inhibit in a dose-dependent fashion thrombin-induced aggregation and serotonin release with IC50 values in the 10-35 microM concentration range.	Tyrphostins	40-51	coagulation factor II, thrombin	Homo sapiens	89-97	
8391259-2	1993	Using the potent tyrosine kinase inhibitor tyrphostin AG-213, we have observed a significant inhibition of aggregation and 5-hydroxytryptamine release; however, this percentage inhibition was lower at high thrombin concentrations.	Tyrphostins	43-53	coagulation factor II, thrombin	Homo sapiens	206-214	
8391259-3	1993	On the other hand, tyrphostin treatment of metabolically 32P-labelled platelets significantly inhibited the thrombin-dependent accumulation of PtdIns(3,4)P2, which involves at least a PtdIns 3-kinase and/or a PtdIns3P 4-kinase, whereas the synthesis of phosphatidic acid (PtdOH), a good reflection of the phospholipase C (PLC) activation in platelets, was partially blocked.	Tyrphostins	19-29	coagulation factor II, thrombin	Homo sapiens	108-116	
8391259-4	1993	Inositol phosphate production was also inhibited by about 40% when tyrphostin-treated platelets were stimulated with thrombin.	Tyrphostins	67-77	coagulation factor II, thrombin	Homo sapiens	117-125	
1382425-4	1992	Tyrphostins decreased [32P]phosphatidic acid production induced by thrombin, although never by more than 50%, and only delayed the peak of diacylglycerol, suggesting that phospholipase C was still activated.	Tyrphostins	0-11	coagulation factor II, thrombin	Homo sapiens	67-75	
1382425-5	1992	Tyrphostins inhibited the thrombin-elicited early phosphorylation of p43 and p20, substrates for protein kinase C (PKC) and myosin light chain kinase, respectively, at short times of activation.	Tyrphostins	0-11	coagulation factor II, thrombin	Homo sapiens	26-34	
1382425-9	1992	The ability of tyrphostins to inhibit phosphorylation of p43 and p20 when induced by thrombin but not when induced by PMA confirms that PTKs may be involved subsequent to PKC activation.	Tyrphostins	15-26	coagulation factor II, thrombin	Homo sapiens	85-93	
2133252-3	1990	Tyrphostins inhibited dose-dependently thrombin-induced aggregation and the release reaction, with a maximum effect at 25 microM.	Tyrphostins	0-11	coagulation factor II, thrombin	Homo sapiens	39-47	
2133252-4	1990	Using immunoblots of platelet proteins revealed with an anti-phosphotyrosine antibody, tyrphostins were effective inhibitors of tyrosine phosphorylation elicited by thrombin.	Tyrphostins	87-98	coagulation factor II, thrombin	Homo sapiens	165-173