PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10976912-2 2000 A specific EGF receptor kinase inhibitor, tyrphostin AG1478, substantially reduced TRH-stimulated tyrosine phosphorylation of the EGF receptor. Tyrphostins 42-52 epidermal growth factor receptor Rattus norvegicus 11-23 29951953-7 2018 Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells. Tyrphostins 112-122 epidermal growth factor receptor Rattus norvegicus 77-81 29951953-7 2018 Further studies showed that EGFL7 knockdown or pharmacological inhibition of EGFR-pathway, using EGFR inhibitor Tyrphostin AG-1478, significantly suppressed migration and invasion of GH3 and GT1-1 cells. Tyrphostins 112-122 epidermal growth factor receptor Rattus norvegicus 97-101 25813982-5 2016 In vitro, EGFR inhibition by Tyrphostin (Tyr), Cl-387785 or its knockdown with siRNA strongly prevented E17G-induced impairment of Abcc2 function and localization. Tyrphostins 29-39 epidermal growth factor receptor Rattus norvegicus 10-14 25813982-5 2016 In vitro, EGFR inhibition by Tyrphostin (Tyr), Cl-387785 or its knockdown with siRNA strongly prevented E17G-induced impairment of Abcc2 function and localization. Tyrphostins 29-32 epidermal growth factor receptor Rattus norvegicus 10-14 25813982-7 2016 The protection of Tyr was not additive to that produced by the ERalpha inhibitor ICI neither with that produced by Src kinase inhibitors, suggesting that EGFR shared the signaling pathway of ERalpha and Src. Tyrphostins 18-21 epidermal growth factor receptor Rattus norvegicus 154-158 22646904-0 2012 The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction. Tyrphostins 35-45 epidermal growth factor receptor Rattus norvegicus 4-8 18848961-3 2009 In this work we show that in FaO rat hepatoma cells inhibition of the epidermal growth factor receptor (EGFR) with the tyrphostin AG1478 enhances TGF-beta-induced cell death, coincident with an elevated increase in ROS production and GSH depletion. Tyrphostins 119-129 epidermal growth factor receptor Rattus norvegicus 70-102 18848961-3 2009 In this work we show that in FaO rat hepatoma cells inhibition of the epidermal growth factor receptor (EGFR) with the tyrphostin AG1478 enhances TGF-beta-induced cell death, coincident with an elevated increase in ROS production and GSH depletion. Tyrphostins 119-129 epidermal growth factor receptor Rattus norvegicus 104-108 16534669-5 2006 Submaximal histamine-stimulated acid secretion was increased significantly by the EGFR inhibitors tyrphostin (Tyr) A46 and Tyr AG1478. Tyrphostins 98-108 epidermal growth factor receptor Rattus norvegicus 82-86 16534669-5 2006 Submaximal histamine-stimulated acid secretion was increased significantly by the EGFR inhibitors tyrphostin (Tyr) A46 and Tyr AG1478. Tyrphostins 110-113 epidermal growth factor receptor Rattus norvegicus 82-86 16534669-5 2006 Submaximal histamine-stimulated acid secretion was increased significantly by the EGFR inhibitors tyrphostin (Tyr) A46 and Tyr AG1478. Tyrphostins 123-126 epidermal growth factor receptor Rattus norvegicus 82-86 16534669-7 2006 Histamine caused a fourfold increase in EGFR phosphorylation which was inhibited by both Tyr and ranitidine. Tyrphostins 89-92 epidermal growth factor receptor Rattus norvegicus 40-44 14563668-9 2004 Selective EGFR tyrosine kinase inhibitor tyrphostin AG1478 almost completely inhibited HDC and VMAT2 gene expression induced by TGF-alpha in vivo and in vitro. Tyrphostins 41-51 epidermal growth factor receptor Rattus norvegicus 10-14 12107054-4 2002 Specific inhibition of EGFR kinase activity by tyrphostin AG-1478 or expression of a dominant-negative EGFR mutant abolished this response. Tyrphostins 47-57 epidermal growth factor receptor Rattus norvegicus 23-27 10976912-2 2000 A specific EGF receptor kinase inhibitor, tyrphostin AG1478, substantially reduced TRH-stimulated tyrosine phosphorylation of the EGF receptor. Tyrphostins 42-52 epidermal growth factor receptor Rattus norvegicus 130-142 10516208-5 1999 The tyrphostin AG-1478, which inhibits the tyrosine kinase activity of the EGFR, but not the tyrphostin A-10, which does not affect EGFR activity, significantly ameliorated asbestos-induced increases in mRNA levels of c-fos but not of c-jun. Tyrphostins 4-14 epidermal growth factor receptor Rattus norvegicus 75-79 26368632-6 2000 Crocidolite induced AP-I in RPM cells in a dose-dependent manner, and this induction of AP-I in RPM cells was inhibited by coincubation with tyrphostin AG 1478, a potent inhibitor of the EGF-R. Tyrphostins 141-151 epidermal growth factor receptor Rattus norvegicus 187-192 11601336-6 1999 Tyrphostin AG1478, a selective inhibitor of EGF receptor, strongly suppressed GH-induced ERK activation, while tyrphostin AG1295, a selective inhibitor of PDGF receptor, had no effects on the activation of ERKs stimulated by GH in cardiac myocytes. Tyrphostins 0-10 epidermal growth factor receptor Rattus norvegicus 44-56 10393853-2 1999 In this study we have used tyrosine kinase inhibitors of the tyrphostin class to specifically block autophosphorylation of the platelet-derived growth factor receptor (PDGF-R) or epidermal growth factor receptor (EGF-R). Tyrphostins 61-71 epidermal growth factor receptor Rattus norvegicus 179-211 10393853-2 1999 In this study we have used tyrosine kinase inhibitors of the tyrphostin class to specifically block autophosphorylation of the platelet-derived growth factor receptor (PDGF-R) or epidermal growth factor receptor (EGF-R). Tyrphostins 61-71 epidermal growth factor receptor Rattus norvegicus 213-218 10092515-7 1999 Tyrphostin AG1478, an EGFR-specific tyrosine kinase inhibitor, mimicked the effects of chronic ethanol on EGFR phosphorylation, PLC-gamma1 translocation and interactions between EGFR and PLC-gamma1 in the cytoskeleton. Tyrphostins 0-10 epidermal growth factor receptor Rattus norvegicus 22-26 9722539-8 1998 AG1478, a tyrphostin selective for the EGF receptor, reduced the activation of MAP kinase, the tyrosine phosphorylation of SHC, the association of Grb2 with SHC, and the tyrosine phosphorylation of the EGF receptor and p120(cbl) but did not block the tyrosine phosphorylation of RAFTK. Tyrphostins 10-20 epidermal growth factor receptor Rattus norvegicus 39-51 8596637-4 1996 Specific inhibition of EGFR function by either the selective tyrphostin AG1478 or a dominant-negative EGFR mutant suppressed MAP kinase activation and strongly inhibited induction of fos gene expression and DNA synthesis. Tyrphostins 61-71 epidermal growth factor receptor Rattus norvegicus 23-27 9710602-7 1998 The arsenite-induced tyrosine phosphorylation of Shc, enhancement of Shc and Grb2 interactions, and activation of ERK were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478. Tyrphostins 263-273 epidermal growth factor receptor Rattus norvegicus 238-242 9016808-7 1997 The EGF-induced effect on deoxynucleic acid synthesis was inhibited by transforming growth factor-beta and tyrphostin, a tyrosine kinase inhibitor that blocks the phosphorylation of tyrosine residues on EGF-R. Tyrphostins 107-117 epidermal growth factor receptor Rattus norvegicus 203-208