PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22465472-6 2012 In rats, SM induced a burst of pro-inflammatory cytokines/chemokines within 72 h, including IL-1beta, TNF-alpha, IL-2, IL-6, CCL2, CCL3, CCL11, and CXCL1 that was associated with neutrophilic infiltration into the lung. Mustard Gas 9-11 tumor necrosis factor Rattus norvegicus 102-111 20659490-8 2010 SM exposure also resulted in increased expression of markers of inflammation including cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-9 (MMP-9), each of which has been implicated in pulmonary toxicity. Mustard Gas 0-2 tumor necrosis factor Rattus norvegicus 113-140 20659490-8 2010 SM exposure also resulted in increased expression of markers of inflammation including cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-9 (MMP-9), each of which has been implicated in pulmonary toxicity. Mustard Gas 0-2 tumor necrosis factor Rattus norvegicus 142-150 34390737-0 2021 Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by anti-tumor necrosis factor-alpha antibody. Mustard Gas 65-79 tumor necrosis factor Rattus norvegicus 103-130 34390737-8 2021 Anti-TNFalpha antibody was found to blunt SM-induced peribronchial edema, perivascular inflammation and alveolar plasma protein and inflammatory cell accumulation in the lung; this was associated with reduced expression of PCNA in histologic sections and decreases in BAL levels of fibrinogen. Mustard Gas 42-44 tumor necrosis factor Rattus norvegicus 5-13 34390737-9 2021 SM-induced increases in inflammatory proteins including soluble receptor for glycation end products, its ligand, high mobility group box-1, and matrix metalloproteinase-9 were also reduced by anti-TNFalpha antibody administration, along with increases in numbers of lung macrophages expressing TNFalpha, cyclooxygenase-2 and inducible nitric oxide synthase. Mustard Gas 0-2 tumor necrosis factor Rattus norvegicus 197-205 34390737-9 2021 SM-induced increases in inflammatory proteins including soluble receptor for glycation end products, its ligand, high mobility group box-1, and matrix metalloproteinase-9 were also reduced by anti-TNFalpha antibody administration, along with increases in numbers of lung macrophages expressing TNFalpha, cyclooxygenase-2 and inducible nitric oxide synthase. Mustard Gas 0-2 tumor necrosis factor Rattus norvegicus 294-302 34390737-11 2021 Together, these data suggest that inhibiting TNFalpha may represent an efficacious approach to mitigating acute lung injury, inflammatory macrophage activation, and oxidative stress induced by inhaled sulfur mustard. Mustard Gas 201-215 tumor necrosis factor Rattus norvegicus 45-53