PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34397154-6 2022 TTR was extracted from SM-treated plasma by immunomagnetic separation (IMS) and analyzed after tryptic cleavage by microbore liquid chromatography-electrospray ionization high-resolution tandem-mass spectrometry (muLC-ESI MS/HR MS). Mustard Gas 23-25 transthyretin Homo sapiens 0-3 34397154-7 2022 It was found that the Cys10 -residue of TTR present in the hexapeptide C(-HETE)PLMVK was alkylated by the hydroxyethylthioethyl (HETE)-moiety, which is characteristic for SM exposure. Mustard Gas 171-173 transthyretin Homo sapiens 40-43 34397154-8 2022 It was shown that alkylated TTR is stable in plasma in vitro at 37 C for at least 14 d. In addition, C(-HETE)PLMVK can be selectively detected, is stable in the autosampler over 24 h and shows linearity in a broad concentration range from 15.63 muM to 2 mM SM in plasma in vitro. Mustard Gas 257-259 transthyretin Homo sapiens 28-31