PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10999955-5	2000	15d-PGJ(2) was found to inhibit the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which mediates cyclin D1 expression.	15d-pgj	0-7	cyclin D1	Homo sapiens	117-126	
12354750-4	2002	Treatment of MCF-7 cells with 15d-PGJ(2) leads to a rapid increase in the phosphorylation of protein synthesis initiation factor eukaryotic initiation factor 2alpha (eIF-2alpha) and a shift of cyclin D1 mRNA from the polysome-associated to free mRNA fraction, indicating that 15d-PGJ(2) inhibits the initiation of cyclin D1 mRNA translation.	15d-pgj	30-37	cyclin D1	Homo sapiens	193-202	
12354750-4	2002	Treatment of MCF-7 cells with 15d-PGJ(2) leads to a rapid increase in the phosphorylation of protein synthesis initiation factor eukaryotic initiation factor 2alpha (eIF-2alpha) and a shift of cyclin D1 mRNA from the polysome-associated to free mRNA fraction, indicating that 15d-PGJ(2) inhibits the initiation of cyclin D1 mRNA translation.	15d-pgj	30-37	cyclin D1	Homo sapiens	314-323	
11287611-7	2001	The inhibition of S-phase entry and activity of the cyclin D1-dependent serine-threonine kinase (Cdk) by 15d-PGJ(2) was not observed in PPARgamma-deficient cells.	15d-pgj	105-112	cyclin D1	Homo sapiens	52-61	
11287611-8	2001	Cyclin D1 overexpression reversed the S-phase inhibition by 15d-PGJ(2).	15d-pgj	60-67	cyclin D1	Homo sapiens	0-9