PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12435328-5	2002	This study showed that the PPARgamma agonist, 15d-PGJ(2), exerts a dual effect on COX-2 production.	15d-pgj	46-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87	
15821150-5	2005	At low concentrations (<0.1 microM), 15d-PGJ(2) inhibited IL-1beta-stimulated prostaglandin E(2) (PGE(2)) but not cytokine (IL-6/IL-8) production or cyclooxygenase-2 (COX-2) expression.	15d-pgj	40-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	152-168	
15317873-11	2004	Micromolar concentrations of 15d-PGJ(2) inhibit cytokine-elicited levels of inducible nitricoxide synthase, cyclooxygenase-2, and intercellular adhesion molecule-1 in MC.	15d-pgj	29-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-163	
12455057-2	2003	The purpose of our study was to examine the relationship between COX-2 (with the resulting prostaglandins E(2), PGE(2)) and PPARgamma (and its natural endogenous ligand 15-Deoxy-Delta(12,14)-prostaglandin J(2), 15d-PGJ(2)) at various stages during the development of human breast cancer and its progression to metastasis.	15d-pgj	211-218	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70	
21236332-4	2011	15d-PGJ(2) induced the accumulation of reactive oxygen species (ROS) that in turn may lead to upregulation of Cox-2 via two different routes in a PPARgamma-independent manner.	15d-pgj	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-115	
21236332-6	2011	Second, 15d-PGJ(2) induces activation of epidermal growth factor receptors and downstream activation of Cox-2 via phosphorylation of p42/44 MAPK.	15d-pgj	8-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-109	
18192694-6	2008	Furthermore, 15d-PGJ(2) formed reactive oxygen species, which led to increased phosphorylation of Akt, DNA binding of AP-1 and expression of COX-2.	15d-pgj	13-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	141-146	
18192694-8	2008	Taken together, these observations suggest that 15d-PGJ(2) produced by COX-2 overexpression may function as a positive regulator of COX-2 in human breast cancer MCF-7 cells.	15d-pgj	48-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	71-76	
18192694-8	2008	Taken together, these observations suggest that 15d-PGJ(2) produced by COX-2 overexpression may function as a positive regulator of COX-2 in human breast cancer MCF-7 cells.	15d-pgj	48-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-137	
10827178-4	2000	Here, we show that 15d-PGJ(2) suppresses the lipopolysaccharide (LPS)-induced expression of COX-2 in the macrophage-like differentiated U937 cells but not in vascular endothelial cells.	15d-pgj	19-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97