PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15316561-2	2004	We recently showed that treatment with 15d-PGJ(2) induces apoptosis accompanied by downregulation of the oncogenic signal transducer and activator of transcription 3 (Stat3) signalling in human oral squamous cell carcinoma (SCC) cells.	15d-pgj	39-46	signal transducer and activator of transcription 3	Homo sapiens	115-165	
16000871-5	2005	15d-PGJ(2) blocked IL-6 induced Stat1 and Stat3 activation in primary human lymphocytes, Jurkat cells and immortalized rheumatoid arthritis B cells.	15d-pgj	0-7	signal transducer and activator of transcription 3	Homo sapiens	42-47	
16000871-8	2005	Although cycloheximide reversed 15d-PGJ(2)-mediated inhibition of Stat3 activation, actinomycin D had no effect on 15d-PGJ(2)-mediated inhibition of IL-6 signaling, indicating that inhibition of IL-6 signaling occur independent of de novo gene expression.	15d-pgj	32-39	signal transducer and activator of transcription 3	Homo sapiens	66-71	
15316561-2	2004	We recently showed that treatment with 15d-PGJ(2) induces apoptosis accompanied by downregulation of the oncogenic signal transducer and activator of transcription 3 (Stat3) signalling in human oral squamous cell carcinoma (SCC) cells.	15d-pgj	39-46	signal transducer and activator of transcription 3	Homo sapiens	167-172	
15316561-4	2004	Inhibition of Stat3 by 15d-PGJ(2) was abolished by exogenous stimulation with transforming growth factor alpha (TGF-alpha), but not interleukin 6 (IL-6), supporting a selective effect of 15d-PGJ(2) on IL-6-mediated signalling.	15d-pgj	23-30	signal transducer and activator of transcription 3	Homo sapiens	14-19	
15316561-8	2004	Our findings provide the first evidence for 15d-PGJ(2)-mediated downregulation of constitutive and IL-6-induced JAK signalling in cancer and support that JAK inhibition and suppression of EGFR-independent Stat3 activation by 15d-PGJ(2) represent a promising approach for induction of apoptosis in oral SCC cells.	15d-pgj	44-51	signal transducer and activator of transcription 3	Homo sapiens	205-210	
16413037-2	2006	15d-PGJ(2) was found to abrogate phosphorylation on tyr705 of STAT3 in IL-6-treated ECs, in a dose- and time-dependent manner, but did not inhibit serine phosphorylation of STAT3 and the upperstream JAK2 phosphorylation.	15d-pgj	0-7	signal transducer and activator of transcription 3	Homo sapiens	62-67	
16413037-2	2006	15d-PGJ(2) was found to abrogate phosphorylation on tyr705 of STAT3 in IL-6-treated ECs, in a dose- and time-dependent manner, but did not inhibit serine phosphorylation of STAT3 and the upperstream JAK2 phosphorylation.	15d-pgj	0-7	signal transducer and activator of transcription 3	Homo sapiens	173-178	
16413037-9	2006	NAC, glutathione and DTT all reversed the inhibition of STAT3 phosphorylation when preincubated with 15d-PGJ(2).	15d-pgj	101-108	signal transducer and activator of transcription 3	Homo sapiens	56-61	
16413037-11	2006	Taken together, these results suggest that 15d-PGJ(2) inhibits IL-6-stimulated phosphorylation on tyr705 of STAT3 dependent on its own electrophilic reactivity in ECs.	15d-pgj	43-50	signal transducer and activator of transcription 3	Homo sapiens	108-113