PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22991494-10	2012	15d-PGJ(2) also increased the expression levels of phospho-c-Jun N terminal kinase (JNK) in Caki-2 cells, and decreased those of phospho-Akt in 786-O cells, indicating that the JNK MAPK and the Akt pathways participated in the anticancer effects of 15d-PGJ(2) in some cell lines.	15d-pgj	0-7	mitogen-activated protein kinase 8	Homo sapiens	51-82	
22991494-10	2012	15d-PGJ(2) also increased the expression levels of phospho-c-Jun N terminal kinase (JNK) in Caki-2 cells, and decreased those of phospho-Akt in 786-O cells, indicating that the JNK MAPK and the Akt pathways participated in the anticancer effects of 15d-PGJ(2) in some cell lines.	15d-pgj	0-7	mitogen-activated protein kinase 8	Homo sapiens	84-87	
22991494-10	2012	15d-PGJ(2) also increased the expression levels of phospho-c-Jun N terminal kinase (JNK) in Caki-2 cells, and decreased those of phospho-Akt in 786-O cells, indicating that the JNK MAPK and the Akt pathways participated in the anticancer effects of 15d-PGJ(2) in some cell lines.	15d-pgj	0-7	mitogen-activated protein kinase 8	Homo sapiens	177-180	
22991494-10	2012	15d-PGJ(2) also increased the expression levels of phospho-c-Jun N terminal kinase (JNK) in Caki-2 cells, and decreased those of phospho-Akt in 786-O cells, indicating that the JNK MAPK and the Akt pathways participated in the anticancer effects of 15d-PGJ(2) in some cell lines.	15d-pgj	249-256	mitogen-activated protein kinase 8	Homo sapiens	177-180	
22991494-12	2012	In addition, the JNK MAPK and Akt pathway was involved in the cytotoxicity of 15d-PGJ(2) to some extent in some cell line.	15d-pgj	78-85	mitogen-activated protein kinase 8	Homo sapiens	17-20	
18718914-4	2008	Moreover, 15d-PGJ(2) activated JNK and p38 MAPK while inducing p53 phosphorylation at sites responsible for p53 activity.	15d-pgj	10-17	mitogen-activated protein kinase 8	Homo sapiens	31-34	
19429239-5	2009	15d-PGJ(2) suppressed TGF-beta-induced Smad2 phosphorylation, however enhancing the phosphorylation of ERK, c-Jun N-terminal kinase (JNK), and p38 in TGF-beta-treated Hep3B cells.	15d-pgj	0-7	mitogen-activated protein kinase 8	Homo sapiens	108-131	
19429239-5	2009	15d-PGJ(2) suppressed TGF-beta-induced Smad2 phosphorylation, however enhancing the phosphorylation of ERK, c-Jun N-terminal kinase (JNK), and p38 in TGF-beta-treated Hep3B cells.	15d-pgj	0-7	mitogen-activated protein kinase 8	Homo sapiens	133-136	
18718914-5	2008	JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) pretreatment attenuated 15d-PGJ(2)-mediated apoptosis and suppressed the p21(Waf1) and Bax expressions without affecting p53 protein accumulation.	15d-pgj	82-89	mitogen-activated protein kinase 8	Homo sapiens	0-3	
18718914-10	2008	This is the first study that 15d-PGJ(2) induces vascular endothelial cell apoptosis through the signaling of JNK and p38 MAPK-mediated p53 activation both in vitro and in vivo, further establishing the potential of 15d-PGJ(2) as an anti-angiogenesis agent.	15d-pgj	29-36	mitogen-activated protein kinase 8	Homo sapiens	109-112	
14998722-6	2004	Although 15d-PGJ(2) significantly activated the MAPKs of JNK and ERK, the activation of JNK and ERK did not contribute to the induction of HO-1 as determined using transfection of dominant-negative plasmids and MAPKs inhibitors.	15d-pgj	9-16	mitogen-activated protein kinase 8	Homo sapiens	57-60	
15289320-6	2004	Second, 15d-PGJ(2) selectively inhibited c-Jun NH(2) terminal kinase (JNK) but not extracellular signal-regulated kinase or p38 mitogen-activated protein kinase activation induced by PMA.	15d-pgj	8-15	mitogen-activated protein kinase 8	Homo sapiens	41-68	
15289320-6	2004	Second, 15d-PGJ(2) selectively inhibited c-Jun NH(2) terminal kinase (JNK) but not extracellular signal-regulated kinase or p38 mitogen-activated protein kinase activation induced by PMA.	15d-pgj	8-15	mitogen-activated protein kinase 8	Homo sapiens	70-73	
12720296-4	2003	Moreover, 15d-PGJ(2) and PGA(1) activated the c-jun N-terminal kinase (JNK) and caspase-3 activity in dose- and time-dependent manners.	15d-pgj	10-17	mitogen-activated protein kinase 8	Homo sapiens	46-69	
12720296-4	2003	Moreover, 15d-PGJ(2) and PGA(1) activated the c-jun N-terminal kinase (JNK) and caspase-3 activity in dose- and time-dependent manners.	15d-pgj	10-17	mitogen-activated protein kinase 8	Homo sapiens	71-74	
12720296-6	2003	Overexpression of DN-JNK significantly repressed both endogenous JNK and caspase-3 activity, and subsequently decreased apoptosis induced by 15d-PGJ(2) and PGA(1).	15d-pgj	141-148	mitogen-activated protein kinase 8	Homo sapiens	21-24	
12720296-7	2003	These results suggested that CyPGs, such as 15d-PGJ(2) and PGA(1), activated JNK signaling pathway, and that JNK activation may be involved in 15d-PGJ(2)- and PGA(1)-induced apoptosis.	15d-pgj	44-51	mitogen-activated protein kinase 8	Homo sapiens	77-80	
12720296-7	2003	These results suggested that CyPGs, such as 15d-PGJ(2) and PGA(1), activated JNK signaling pathway, and that JNK activation may be involved in 15d-PGJ(2)- and PGA(1)-induced apoptosis.	15d-pgj	143-150	mitogen-activated protein kinase 8	Homo sapiens	109-112