PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26037925-3 2015 To establish the hypusine modification system as a novel platform for therapeutic strategies, we aimed to investigate its functional relevance in mammals by generating and using a range of new knock-out mouse models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as well as for the cancer-related isoform eIF-5A2. hypusine 17-25 deoxyhypusine synthase Mus musculus 251-273 34496231-2 2021 Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. hypusine 95-103 deoxyhypusine synthase Mus musculus 13-35 22694849-1 2012 BACKGROUND: Deoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum. hypusine 17-25 deoxyhypusine synthase Mus musculus 36-39 34688659-2 2021 Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH). hypusine 0-8 deoxyhypusine synthase Mus musculus 78-100 34688659-2 2021 Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH). hypusine 0-8 deoxyhypusine synthase Mus musculus 102-106 21850436-2 2012 Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH). hypusine 0-8 deoxyhypusine synthase Mus musculus 156-178 21850436-2 2012 Hypusine is formed post-translationally by the addition of the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue, catalyzed by deoxyhypusine synthase (DHPS), and subsequent hydroxylation by deoxyhypusine hydroxylase (DOHH). hypusine 0-8 deoxyhypusine synthase Mus musculus 180-184 9149130-7 1997 The large difference, >30-fold, in hypusine formation activity between these two cells is mainly due to difference in the amount of newly synthesized eIF-5A precursor rather than deoxyhypusine synthase. hypusine 38-46 deoxyhypusine synthase Mus musculus 182-204 34496231-2 2021 Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. hypusine 95-103 deoxyhypusine synthase Mus musculus 37-41 34496231-2 2021 Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. hypusine 105-108 deoxyhypusine synthase Mus musculus 13-35 34496231-2 2021 Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. hypusine 105-108 deoxyhypusine synthase Mus musculus 37-41 34216540-4 2021 Polyamines control TH differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine, and mice in which T cells are deficient for hypusine develop severe intestinal inflammatory disease. hypusine 123-131 deoxyhypusine synthase Mus musculus 66-88