PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10512614-6	1999	Through kinetic evaluation of DPP-IV inhibition by the D-antipode, des-cyano, and amide analogues of NVP-DPP728, it was determined that the nitrile functionality at the 2-pyrrolidine position is required, in the L-configuration, for maximal activity (K(i) of 11 nM vs K(i) values of 5.6 to >300 microM for the other analogues tested).	dpp728	105-111	dipeptidyl peptidase 4	Homo sapiens	30-36	
12036346-3	2002	One compound, NVP-DPP728 (2), is profiled as a potent, selective, and short-acting DPP-IV inhibitor that has excellent oral bioavailability and potent antihyperglycemic activity.	dpp728	18-24	dipeptidyl peptidase 4	Homo sapiens	83-89	
10512614-8	1999	NVP-DPP728 inhibited DPP-IV in a manner consistent with a two-step inhibition mechanism.	dpp728	4-10	dipeptidyl peptidase 4	Homo sapiens	21-27	
10512614-9	1999	Taken together, these data suggest that NVP-DPP728 inhibits DPP-IV through formation of a novel, reversible, nitrile-dependent complex with transition state characteristics.	dpp728	44-50	dipeptidyl peptidase 4	Homo sapiens	60-66