PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12772586-1	2003	In an air pouch-type carrageenin-induced inflammation model in rats, the selective cyclooxygenase (COX)-2 inhibitor NS-398 dose dependently inhibited the granulation tissue formation, angiogenesis and the level of vascular endothelial growth factor (VEGF) in the granulation tissue.	Carrageenan	21-32	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	83-105	
15448533-10	2004	Western blot analysis showed that the concentrations of both COX-1 and COX-2 in the skin increased after carrageenan.	Carrageenan	105-116	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	71-76	
15324899-1	2004	The introduction of 3-arylmethyl, 3-aryloxy and 3-arylthio moieties into a 6-methylsulfonylindole framework using rational drug design led to potent, selective COX-2 inhibitors having efficacy in a rat carrageenan air pouch model.	Carrageenan	202-213	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	160-165	
15370364-9	2004	COX-2 protein was markedly elevated 4 hours after injection of carrageenan.	Carrageenan	63-74	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
11046121-11	2000	These findings suggest that COX-2-derived PGE(2) plays a significant role in angiogenesis in the carrageenin-induced granulation tissue through VEGF formation.	Carrageenan	97-108	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	28-33	
9309800-2	1997	In rat carrageenin-induced pleurisy, the plasma exudation rate peaked at 5 h, at which time COX-2 was detectable in cells from the pleural exudate.	Carrageenan	7-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	92-97	
9831332-1	1998	Cyclooxygenase (COX)-2 was induced in an acute exudative inflammatory model (rat carrageenin-induced pleurisy) in which prostaglandin E2, 6-keto-prostaglandin F1alpha, and thromboxane B2 were generated in the pleural fluid.	Carrageenan	81-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-22	
10371510-11	1999	Thus, COX 2 may be pro-inflammatory during the early phase of a carrageenin-induced pleurisy, dominated by polymorphonuclear leucocytes, but may aid resolution at the later, mononuclear cell-dominated phase by generating an alternative set of anti-inflammatory prostaglandins.	Carrageenan	64-75	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	6-11	
10503963-1	1999	We have previously shown that the inducible isoform of the cyclooxygenases, COX-2, is strongly expressed in pleural exudate leukocytes early (between 3 and 7 hr after irritation) during rat carrageenin-induced pleurisy.	Carrageenan	190-201	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	76-81	
9618405-0	1998	Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats.	Carrageenan	69-80	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	20-25	
34931968-7	2021	All synthesized compounds were screened for their binding potential in the protein pocket of COX-2 and evaluated for their anti-inflammatory potential in animals using the carrageenan-induced paw edema method.	Carrageenan	172-183	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	93-98	
7532080-12	1994	In pleural exudate cell pellets, COX activity peaked at 2 to 6 h after injection of the carrageenin.	Carrageenan	88-99	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	33-36	
7532080-20	1994	In cell pellet smears from carrageenin-induced pleurisy taken 2 h after injection of the irritant, PMNs were also the major source of COX-2 immunoreactivity.	Carrageenan	27-38	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	134-139	
7532080-24	1994	The present results illustrated a similar profile of COX and NOS activity in the carrageenin-induced pleurisy model of acute inflammation.	Carrageenan	81-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	53-56	
9253772-3	1997	COX-2 is induced not only in acute exudative rat carrageenin-induced pleurisy, but in granuloma formation/proliferative inflammation for the acceleration of angiogenesis.	Carrageenan	49-60	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
28765972-8	2017	YNB Inhibited the production of the COX-2 AA metabolite prostaglandin E2 (PGE2) and suppressed expression of COX-2, cPLA2, PGE2 mRNA in the carrageenan-induced inflammation mode (P<0.05).	Carrageenan	140-151	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	36-41	
29946770-4	2019	The levels of prostaglandin E2 (PGE2), cyclooxygenase-1 (COX-1), and COX-2 in carrageenan-induced rat paw swelling and gastric mucosa were detected by enzyme-linked immunosorbent assay (ELISA).	Carrageenan	78-89	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	69-74	
29946770-5	2019	COX-1 and COX-2 expressions in carrageenan-induced rat paw swelling and gastric mucosa were detected by western blotting.	Carrageenan	31-42	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	10-15	
30996860-0	2019	Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition.	Carrageenan	61-72	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	102-107	
30622412-7	2019	Western blotting results revealed that rhein diminished carrageenan-induced cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) and increased heme oxygenase (HO)-1, nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPAR)-gamma and heat shock protein (HSP)-72 expression after 6 h in the paw oedema model.	Carrageenan	56-67	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	76-98	
28765972-8	2017	YNB Inhibited the production of the COX-2 AA metabolite prostaglandin E2 (PGE2) and suppressed expression of COX-2, cPLA2, PGE2 mRNA in the carrageenan-induced inflammation mode (P<0.05).	Carrageenan	140-151	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	109-114	
28013183-1	2017	In this work, novel series of pyran, thiophene and thienopyrimidine derivatives based on 2-acetamide-thiadiazole scaffold were designed and synthesized for evaluation as selective COX-2 inhibitors in-vitro and investigated in-vivo as anti-inflammatory and analgesic agents against carrageenan-induced rat paw oedema model in irradiated rats, since its well-known that ionizing radiation plays an important role in exaggerating the inflammatory responses and in enhancing the release of inflammatory mediators in experimental animals.	Carrageenan	281-292	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	180-185	
24532118-0	2014	Low-level laser therapy (LLLT) reduces the COX-2 mRNA expression in both subplantar and total brain tissues in the model of peripheral inflammation induced by administration of carrageenan.	Carrageenan	177-188	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	43-48	
24532118-11	2014	Six hours after carrageenan administration, COX-2 mRNA expression was significantly increased both in the subplantar (2.2-4.1-fold) and total brain (8.65-13.79-fold) tissues.	Carrageenan	16-27	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	44-49	
22363560-1	2012	It was suggested that endocannabinoids are metabolized by cyclooxygenase (COX)-2 in the spinal cord of rats with kaolin/lambda-carrageenan-induced knee inflammation, and that this mechanism contributes to the analgesic effects of COX-2 inhibitors in this experimental model.	Carrageenan	127-138	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	58-80	
24905509-0	2014	Pharmacological characterization of carrageenan induced heat muscle hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors.	Carrageenan	36-47	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	137-142	
24905509-7	2014	The data suggest that selective inhibition of COX-2 produce good anti-inflammatory, analgesic and antihyperalgesic effects on Carrageenan-induced thermal inflammatory hyperalgesia.	Carrageenan	126-137	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	46-51	
23587942-1	2013	We previously reported the expression of cyclooxygenase (COX)-2 in draining lymph nodes during carrageenin-induced pleurisy of rats.	Carrageenan	95-106	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	41-63	
23401543-6	2013	Immunofluorescence analysis demonstrated that the amount of COX-1 and COX-2, constitutively expressed in TRPV-1(+) cells of the DRG, significantly increased after carrageenan or IL-1beta administration.	Carrageenan	163-174	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	70-75	
22373734-8	2012	As significant findings, the present study clarified unique structure-activity relationship of the analogues toward potent and selective COX-2 inhibition in vitro, and identified 2-{6-fluoro-2-[4-methyl-2-pridinyl)carbonyl]-1H-indol-3-yl}acetic acid as a potent and selective COX-2 inhibitor in vitro that demonstrated orally potent anti-inflammation efficacy against carrageenan-induced oedema formation in the foot of SPF/VAF male SD rats as a peripheral inflammation model in vivo.	Carrageenan	368-379	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	137-142	
22373734-8	2012	As significant findings, the present study clarified unique structure-activity relationship of the analogues toward potent and selective COX-2 inhibition in vitro, and identified 2-{6-fluoro-2-[4-methyl-2-pridinyl)carbonyl]-1H-indol-3-yl}acetic acid as a potent and selective COX-2 inhibitor in vitro that demonstrated orally potent anti-inflammation efficacy against carrageenan-induced oedema formation in the foot of SPF/VAF male SD rats as a peripheral inflammation model in vivo.	Carrageenan	368-379	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	276-281	
18814970-4	2008	Resveratrol induced a prolonged antinociceptive effect, which was correlated to the inhibition of COX-2 mRNA increase in DRG and cord elicited by carrageenan.	Carrageenan	146-157	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	98-103	
19735303-0	2010	Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.	Carrageenan	31-42	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	130-135	
18814970-8	2008	In conclusion, the antinociceptive effect exhibited by resveratrol was related to the prevention of COX-2 mRNA increase induced by carrageenan.	Carrageenan	131-142	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	100-105	
16949828-2	2006	Of these prodrugs, the N-propionyl sulfonamide sodium 3k was found to be much superior to the parent compound 3 and other marketed COX-2 inhibitors in carrageenan induced rat paw edema model of inflammation due to highly elevated drug levels in systemic circulation.	Carrageenan	151-162	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	131-136	
17607546-0	2007	COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy.	Carrageenan	81-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-5	
17607546-2	2007	Herein we studied the effect of LLLT on the COX-2 mRNA expression in subplantar tissue taken from rats treated with carrageenan.	Carrageenan	116-127	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	44-49	
17303338-5	2007	In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E(2) (PGE(2)) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS.	Carrageenan	23-34	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	204-226	
17163587-1	2006	We investigated the anti-inflammatory effects of electroacupuncture (EA) on carrageenan-induced inflammatory model in association with peripheral and spinal COX-2 expression.	Carrageenan	76-87	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	157-162	
17163587-4	2006	The expression of cyclooxygenase (COX)-1, COX-2, and inducible nitric oxide synthase (iNOS) was inhibited by 2 Hz EA in carrageenan-injected rat paws.	Carrageenan	120-131	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	42-47