PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12123595-0 2002 Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? pip(3) 49-55 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens 16-22 12123595-2 2002 P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules. pip(3) 39-45 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens 0-6 16301320-5 2006 Phosphorylation of P-Rex1 with protein kinase A (PKA) inhibits the PIP(3)- and Gbetagamma-stimulated P-Rex1 guanine nucleotide exchange activity on Rac. pip(3) 67-73 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens 19-25 21172654-2 2010 Here, we identify the PIP(3)-Gbetagamma-dependent Rac-GEF P-Rex1 as an essential mediator of Rac1 activation, motility, cell growth, and tumorigenesis driven by ErbB receptors in breast cancer cells. pip(3) 22-28 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens 58-64 16301320-5 2006 Phosphorylation of P-Rex1 with protein kinase A (PKA) inhibits the PIP(3)- and Gbetagamma-stimulated P-Rex1 guanine nucleotide exchange activity on Rac. pip(3) 67-73 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Homo sapiens 101-107