PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19759305-5 2009 This unexpected finding coincides with POMC-cell-specific, Stat3-mediated upregulation of SOCS3 expression inhibiting both leptin and insulin signaling as insulin-stimulated PIP(3) (phosphatidylinositol-3,4,5 triphosphate) formation and protein kinase B (AKT) activation in POMC neurons as well as with the fact that insulin"s ability to hyperpolarize POMC neurons is largely reduced in POMC cells of Stat3-C(POMC) mice. pip(3) 174-180 signal transducer and activator of transcription 3 Mus musculus 59-64