PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16134057-14	2005	Dust-induced expression of IL-6 precedes that of TNF and the induction pathways differ with regard to staurosporine sensitivity.	Staurosporine	102-115	interleukin 6	Homo sapiens	27-31	
19923143-6	2010	Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression.	Staurosporine	0-13	interleukin 6	Homo sapiens	70-74	
14586407-3	2003	We further demonstrate that IL-6 protects an esophageal carcinoma cell line CE48T/VGH from apoptosis induced by staurosporine.	Staurosporine	112-125	interleukin 6	Homo sapiens	28-32	
10719304-13	2000	GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine.	Staurosporine	117-130	interleukin 6	Homo sapiens	26-30	
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Staurosporine	176-189	interleukin 6	Homo sapiens	69-82	
10598880-0	1999	Activation of cellular responses to interleukin 6 is blocked by staurosporine.	Staurosporine	64-77	interleukin 6	Homo sapiens	36-49	
10598880-2	1999	The effects of the microbial alkaloid staurosporine (SS) on IL-6 signaling through gp130, and also on the internalization of the IL-6 receptor complex, were studied using HepG2 cells which are well-characterized in their ability to respond to IL-6 by upregulating acute-phase protein production.	Staurosporine	53-55	interleukin 6	Homo sapiens	60-64	
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	interleukin 6	Homo sapiens	67-71	
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	interleukin 6	Homo sapiens	166-170	
10598880-6	1999	The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types.	Staurosporine	15-17	interleukin 6	Homo sapiens	42-46	
10598880-6	1999	The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types.	Staurosporine	15-17	interleukin 6	Homo sapiens	52-56	
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	interleukin 6	Homo sapiens	0-13	
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	interleukin 6	Homo sapiens	15-19	
9184081-6	1997	An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine.	Staurosporine	159-172	interleukin 6	Homo sapiens	68-71	
8440709-10	1993	Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone.	Staurosporine	171-184	interleukin 6	Homo sapiens	38-42	
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 6	Homo sapiens	94-98	
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 6	Homo sapiens	122-126	
1655518-12	1991	Staurosporine blocks cell-scattering caused by TPA but not that caused by IL-6 suggesting that IL-6 and TPA elicit similar phenotypic changes in breast cancer cells via different pathways.	Staurosporine	0-13	interleukin 6	Homo sapiens	95-99	
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 6	Homo sapiens	54-58	
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 6	Homo sapiens	112-116