PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30644597-1 2019 Microsomal epoxide hyrolase 1 (EPHX1) is a critical biotransformation enzyme and participants in both the detoxification and activation of potentially genotoxic epoxides. Epoxy Compounds 161-169 epoxide hydrolase 1 Homo sapiens 31-36 6990840-1 1980 Microsomal epoxide hydrolase (EC 3.3.2.3. ; formerly EC 4.2.1.63) catalyse the hydration of epoxides into trans dihydro-diols, easily excretable hydrophil compounds. Epoxy Compounds 92-100 epoxide hydrolase 1 Homo sapiens 0-28 29605894-10 2018 Since EPHX1 enzyme is essential in cellular defense against epoxides, the diminished enzymatic activity conferred by the variant allele C could explain the risk associations found for i-AML. Epoxy Compounds 60-68 epoxide hydrolase 1 Homo sapiens 6-11 29605894-11 2018 In conclusion, EPHX1 rs1051740 plays an important role in i-AML"s genetic susceptibility by modulating the carcinogenic effects of epoxide exposures in the bone marrow. Epoxy Compounds 131-138 epoxide hydrolase 1 Homo sapiens 15-20 26216302-1 2015 Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Epoxy Compounds 115-123 epoxide hydrolase 1 Homo sapiens 0-28 28071611-1 2016 Microsomal epoxide hydrolase (mEH) is a crucial biotransformation enzyme that has capability to metabolize a large number of structurally divergent, highly reactive epoxides, and numerous environmentally exposed carcinogens. Epoxy Compounds 165-173 epoxide hydrolase 1 Homo sapiens 0-28 27256986-11 2016 The substrate specificity of microsomal epoxide hydrolase should therefore be expanded to include not only epoxides but also the oxetanyl ring system present in AZD1979. Epoxy Compounds 107-115 epoxide hydrolase 1 Homo sapiens 29-57 26216302-1 2015 Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Epoxy Compounds 115-123 epoxide hydrolase 1 Homo sapiens 30-35 24309146-2 2014 To evaluate the selectivity of sEH inhibition, the inhibition of microsomal epoxide hydrolase (mEH), which plays a critical role in detoxification of toxic epoxides, was determined using human liver microsomes. Epoxy Compounds 156-164 epoxide hydrolase 1 Homo sapiens 65-93 22118311-1 2011 BACKGROUND/PURPOSE: Microsomal epoxide hydrolase (EPHX) is an important enzyme that metabolizes harmful reactive epoxides from smoking. Epoxy Compounds 113-121 epoxide hydrolase 1 Homo sapiens 20-48 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Epoxy Compounds 187-195 epoxide hydrolase 1 Homo sapiens 0-28 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Epoxy Compounds 187-195 epoxide hydrolase 1 Homo sapiens 35-40 21983886-1 2012 Microsomal epoxide hydrolase, EPHX1, plays a central role in the detoxification of potentially genotoxic epoxide intermediates. Epoxy Compounds 11-18 epoxide hydrolase 1 Homo sapiens 30-35 21983886-9 2012 In conclusion, individuals with EPHX1 113His/His slow activity genotype may not detoxify reactive carcinogenic epoxides efficiently, binding of reactive epoxides to DNA cause DNA damage. Epoxy Compounds 153-161 epoxide hydrolase 1 Homo sapiens 32-37 22118311-1 2011 BACKGROUND/PURPOSE: Microsomal epoxide hydrolase (EPHX) is an important enzyme that metabolizes harmful reactive epoxides from smoking. Epoxy Compounds 113-121 epoxide hydrolase 1 Homo sapiens 50-54 19364907-1 2009 Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. Epoxy Compounds 11-18 epoxide hydrolase 1 Homo sapiens 30-35 19364907-1 2009 Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. Epoxy Compounds 211-219 epoxide hydrolase 1 Homo sapiens 0-28 19364907-1 2009 Microsomal epoxide hydrolase (EPHX1) biotransforms epoxide derivatives of pharmaceuticals, including metabolites of certain antiepileptic medications, such as phenytoin and carbamazepine, and many environmental epoxides, such as those derived from butadiene, benzene, and carcinogenic polyaromatic hydrocarbons. Epoxy Compounds 211-219 epoxide hydrolase 1 Homo sapiens 30-35 15826809-0 2005 Molecular modelling of human microsomal epoxide hydrolase (EH) by homology with a fungal (Aspergillus niger) EH crystal structure of 1.8 A resolution: structure-activity relationships in epoxides inhibiting EH activity. Epoxy Compounds 187-195 epoxide hydrolase 1 Homo sapiens 29-57 18614560-3 2008 To date, most reported findings have been for EPHX1, particularly in relation to functional variants associated with fast and slow metabolism of epoxide intermediates. Epoxy Compounds 145-152 epoxide hydrolase 1 Homo sapiens 46-51 11471167-4 2001 Microsomal epoxide hydrolase (mEH; gene symbol EPHX1) catalyzes hydrolysis of epoxides. Epoxy Compounds 78-86 epoxide hydrolase 1 Homo sapiens 0-28 15716486-2 2005 In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH; EPHX1) enzyme. Epoxy Compounds 17-25 epoxide hydrolase 1 Homo sapiens 97-125 15716486-2 2005 In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH; EPHX1) enzyme. Epoxy Compounds 17-25 epoxide hydrolase 1 Homo sapiens 132-137 12605384-2 2003 In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH) enzyme. Epoxy Compounds 17-25 epoxide hydrolase 1 Homo sapiens 97-125 11692079-3 2001 The microsomal (EPHX1) and soluble (EPHX2) epoxide hydrolases function to regulate the oxidation status of a wide range of xenobiotic- and lipid-derived substrates; therefore, interindividual variation in these pathways may mitigate epoxide-related cellular injury. Epoxy Compounds 43-50 epoxide hydrolase 1 Homo sapiens 16-21 15535985-1 2004 Human microsomal epoxide hydrolase (EPHX1) is active in the metabolism of many potentially carcinogenic or otherwise genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons. Epoxy Compounds 127-135 epoxide hydrolase 1 Homo sapiens 6-34 15535985-1 2004 Human microsomal epoxide hydrolase (EPHX1) is active in the metabolism of many potentially carcinogenic or otherwise genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons. Epoxy Compounds 127-135 epoxide hydrolase 1 Homo sapiens 36-41 11471167-4 2001 Microsomal epoxide hydrolase (mEH; gene symbol EPHX1) catalyzes hydrolysis of epoxides. Epoxy Compounds 78-86 epoxide hydrolase 1 Homo sapiens 47-52 11758809-1 2001 Microsomal epoxide hydrolase is a biotransformation enzyme which is involved in the hydrolysis of various epoxides and epoxide intermediates. Epoxy Compounds 106-114 epoxide hydrolase 1 Homo sapiens 0-28 10673439-9 2000 CONCLUSIONS: The Aspergillus enzyme provides the first structure of an epoxide hydrolase with strong relationships to the most important enzyme of human epoxide metabolism, the microsomal epoxide hydrolase. Epoxy Compounds 71-78 epoxide hydrolase 1 Homo sapiens 177-205 8819481-1 1996 Microsomal epoxide hydrolase (HYL1) is a single-gene enzyme responsible for the hydrolysis of epoxides derived from the oxidative metabolism of xenobiotics. Epoxy Compounds 94-102 epoxide hydrolase 1 Homo sapiens 0-28 10576413-1 1999 Microsomal epoxide hydrolase catalyses the hydrolysis of epoxides to water-soluble trans-dihydrodiols. Epoxy Compounds 57-65 epoxide hydrolase 1 Homo sapiens 0-28 7769232-1 1995 Microsomal epoxide hydrolase is a xenobiotic metabolizing enzyme that catalyzes the conversion of toxic and carcinogenic epoxides to less toxic dihydrodiols. Epoxy Compounds 121-129 epoxide hydrolase 1 Homo sapiens 0-28 34342583-0 2021 EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Epoxy Compounds 71-78 epoxide hydrolase 1 Homo sapiens 0-5