PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27757735-0	2017	Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1.	Amsacrine	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	128-132	
27757735-4	2017	Amsacrine-induced apoptosis of U937 cells was characterized by caspase-9 and caspase-3 activation, increased intracellular Ca2+ concentration, mitochondrial depolarization, and MCL1 down-regulation.	Amsacrine	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	177-181	
27757735-5	2017	Amsacrine induced MCL1 down-regulation by decreasing its stability.	Amsacrine	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	18-22	
27757735-8	2017	Restoration of ERK phosphorylation and AKT expression abrogated amsacrine-induced MCL1 down-regulation.	Amsacrine	64-73	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	82-86	
27757735-9	2017	Moreover, MCL1 over-expression inhibited amsacrine-induced depolarization of mitochondria membrane and increased the viability of amsacrine-treated cells.	Amsacrine	41-50	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	10-14	
27757735-9	2017	Moreover, MCL1 over-expression inhibited amsacrine-induced depolarization of mitochondria membrane and increased the viability of amsacrine-treated cells.	Amsacrine	130-139	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	10-14	
27757735-10	2017	Taken together, our data indicate that amsacrine abolishes ERK- and Pin1-mediated stabilization of MCL1 and promotes GSK3beta-mediated degradation of MCL1, leading to activate mitochondria-mediated apoptosis pathway in U937 cells.	Amsacrine	39-48	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	99-103	
27757735-10	2017	Taken together, our data indicate that amsacrine abolishes ERK- and Pin1-mediated stabilization of MCL1 and promotes GSK3beta-mediated degradation of MCL1, leading to activate mitochondria-mediated apoptosis pathway in U937 cells.	Amsacrine	39-48	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	150-154