PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24900444-0 2012 Heteroaromatic Moieties in the Sphingosine Backbone of alpha-Galactosylceramides for Noncovalent Interactions with CD1d. Sphingosine 31-42 CD1d molecule Homo sapiens 115-119 24900444-1 2012 A series of alpha-GalCer analogues containing heterocyclic and aromatic moieties in the sphingosine backbone were synthesized to improve the selectivity in the Th1/Th2 cytokine profile via noncovalent interaction with three aromatic residues at the binding pocket of CD1d. Sphingosine 88-99 CD1d molecule Homo sapiens 267-271 16007090-3 2005 The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C" pocket and the longer acyl chain anchored in the A" pocket. Sphingosine 77-88 CD1d molecule Homo sapiens 47-51 15599405-1 2004 Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the sphingosine-truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. Sphingosine 166-177 CD1d molecule Homo sapiens 24-28 15173890-2 2004 We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphingosine chain determines the duration of NKT cell stimulation by CD1d-associated glycolipids. Sphingosine 174-185 CD1d molecule Homo sapiens 243-247