PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8204660-3	1994	In liver and spleen from NPC patients, a 6- to 24-fold elevation of sphingosine and sphinganine already prominent at the fetal stage of the disease was observed, while no clear increase could be evidenced in brain tissue.	Sphingosine	68-79	NPC intracellular cholesterol transporter 1	Homo sapiens	25-28	
25946402-6	2016	Niemann-Pick disease type C is a rare, devastating, inherited lysosomal storage disease with a unique cellular phenotype characterized by lysosomal accumulation of sphingosine, various glycosphingolipids and cholesterol and a reduction in lysosomal calcium.	Sphingosine	164-175	NPC intracellular cholesterol transporter 1	Homo sapiens	0-27	
34445564-4	2021	The first trait of NPC is the accumulation of unesterified cholesterol and other lipids, like sphingosine and glycosphingolipids, in the late endosomal and lysosomal compartments, which causes the blockade of autophagic flux and the impairment of mitochondrial functions.	Sphingosine	94-105	NPC intracellular cholesterol transporter 1	Homo sapiens	19-22	
33044062-7	2020	Using our probe, we successfully detected sphingosine accumulation in cells from patients with Niemann-Pick type C1 (NPC1), a lipid transport disorder in which increased sphingosine mediates disease progression.	Sphingosine	42-53	NPC intracellular cholesterol transporter 1	Homo sapiens	95-115	
33044062-7	2020	Using our probe, we successfully detected sphingosine accumulation in cells from patients with Niemann-Pick type C1 (NPC1), a lipid transport disorder in which increased sphingosine mediates disease progression.	Sphingosine	42-53	NPC intracellular cholesterol transporter 1	Homo sapiens	117-121	
33044062-7	2020	Using our probe, we successfully detected sphingosine accumulation in cells from patients with Niemann-Pick type C1 (NPC1), a lipid transport disorder in which increased sphingosine mediates disease progression.	Sphingosine	170-181	NPC intracellular cholesterol transporter 1	Homo sapiens	95-115	
33044062-7	2020	Using our probe, we successfully detected sphingosine accumulation in cells from patients with Niemann-Pick type C1 (NPC1), a lipid transport disorder in which increased sphingosine mediates disease progression.	Sphingosine	170-181	NPC intracellular cholesterol transporter 1	Homo sapiens	117-121	
21344635-1	2011	Niemann-Pick disease type C (NPC) is a rare autosomal recessive lysosomal storage disorder characterized by defective intracellular lipid trafficking, with secondary accumulation of free cholesterol, sphingosine, and glycosphingolipids.	Sphingosine	200-211	NPC intracellular cholesterol transporter 1	Homo sapiens	29-32	
25425283-7	2015	It summarizes the current knowledge on the NPC1 and NPC2 proteins and their function in transport of cholesterol within the late endosomal-lysosomal compartment, with emphasis on differences between systemic organs and the brain; it also discusses regulation by membrane lipids of the NPC2-mediated cholesterol trafficking, interplay between cholesterol and sphingomyelin, the metabolic origin of glycosphingolipids stored in brain, and the putative role of free sphingoid bases in pathogenesis.	Sphingosine	463-472	NPC intracellular cholesterol transporter 1	Homo sapiens	43-47	
22607065-7	2012	Additional evidence against NPC1 playing a significant role in LE/LY sphingosine export was obtained in experiments using the [(3)H]-sphingolipids or a fluorescent sphingosine derivative in NPC1 knock-out cells.	Sphingosine	69-80	NPC intracellular cholesterol transporter 1	Homo sapiens	28-32	
22607065-9	2012	This likely contributes to the increased sphingosine content of NPC1 cells.	Sphingosine	41-52	NPC intracellular cholesterol transporter 1	Homo sapiens	64-68	
21344635-1	2011	Niemann-Pick disease type C (NPC) is a rare autosomal recessive lysosomal storage disorder characterized by defective intracellular lipid trafficking, with secondary accumulation of free cholesterol, sphingosine, and glycosphingolipids.	Sphingosine	200-211	NPC intracellular cholesterol transporter 1	Homo sapiens	0-27	
23881911-7	2013	Plasma MCs and ceramides were elevated, whereas sphingoid bases were reduced in NPC1 subjects.	Sphingosine	48-57	NPC intracellular cholesterol transporter 1	Homo sapiens	80-84