PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21605631-8 2011 Administration of desipramine (a norepinephrine reuptake inhibitor) to Sprague-Dawley rats was sufficient either alone or in combination with stress to increase IL-1beta mRNA in the hypothalamus and desipramine combined with stress was sufficient to increase IL-1R2 mRNA in the hypothalamus. Desipramine 18-29 interleukin 1 beta Rattus norvegicus 161-169 17510525-8 2007 Furthermore, DP treatment significantly inhibited the induction of proinflammatory factor interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in the culture medium of LPS-treated NSCs mediated by Bcl-2 modulation. Desipramine 13-15 interleukin 1 beta Rattus norvegicus 90-112 16386803-6 2006 We found that propranolol blocked the IL-1beta response to footshock in both the hypothalamus and the spleen, while the noradrenergic reuptake inhibitor desipramine significantly augmented the footshock-induced IL-1beta response in both of these sites. Desipramine 153-164 interleukin 1 beta Rattus norvegicus 211-219 10601816-9 2000 Vehicle treated OB rats displayed a significant impairment in LPS-induced IL-1beta (54%) and TNF-alpha (70%) secretion compared to their sham operated controls, an effect that was potentiated following chronic desipramine treatment. Desipramine 210-221 interleukin 1 beta Rattus norvegicus 74-82 10601816-10 2000 Furthermore, sham animals that were chronically treated with desipramine displayed decreases in LPS-provoked IL-1beta (51%) and TNF-alpha (49%) secretion compared to vehicle treated counterparts. Desipramine 61-72 interleukin 1 beta Rattus norvegicus 109-117 26937856-0 2016 Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1beta in the brain and plasma of rats. Desipramine 0-11 interleukin 1 beta Rattus norvegicus 90-98 26937856-2 2016 The present study investigated for the first time the effect of 21-day oral administration of desipramine on the lipopolysaccharide (LPS)-stimulated IL-1beta concentration in the olfactory bulb, hypothalamus, frontal cortex, hippocampus and plasma of rats, and on the LPS-induced IL-1beta mRNA level in the olfactory bulb. Desipramine 94-105 interleukin 1 beta Rattus norvegicus 149-157 26937856-2 2016 The present study investigated for the first time the effect of 21-day oral administration of desipramine on the lipopolysaccharide (LPS)-stimulated IL-1beta concentration in the olfactory bulb, hypothalamus, frontal cortex, hippocampus and plasma of rats, and on the LPS-induced IL-1beta mRNA level in the olfactory bulb. Desipramine 94-105 interleukin 1 beta Rattus norvegicus 280-288 26937856-6 2016 By using the alpha1/alpha2-adrenoceptor antagonist prazosin and the unspecific beta-adrenoceptor antagonist propranolol given prior to LPS, we found that the effect of desipramine on LPS-induced IL-1beta production was partially mediated by both adrenoceptors in the olfactory bulb and plasma, and that beta-adrenoceptors contributed also to its effect on the stimulated IL-1beta concentration in the hypothalamus. Desipramine 168-179 interleukin 1 beta Rattus norvegicus 195-203 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 156-159 interleukin 1 beta Rattus norvegicus 16-33 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 156-159 interleukin 1 beta Rattus norvegicus 35-43 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 220-223 interleukin 1 beta Rattus norvegicus 16-33 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 220-223 interleukin 1 beta Rattus norvegicus 35-43