PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21859713-0	2011	The antidepressant desipramine is an arrestin-biased ligand at the alpha(2A)-adrenergic receptor driving receptor down-regulation in vitro and in vivo.	Desipramine	19-30	adrenoceptor alpha 2A	Homo sapiens	67-96	
25128275-3	2014	Our previous work established a particular TCA, desipramine, as an arrestin-biased alpha2AAR ligand driving receptor endocytosis and downregulation but not canonical heterotrimeric G protein-mediated signaling.	Desipramine	48-59	adrenoceptor alpha 2A	Homo sapiens	83-92	
22405824-0	2012	Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor.	Desipramine	0-11	adrenoceptor alpha 2A	Homo sapiens	90-117	
22405824-2	2012	We have recently identified the tricyclic antidepressant drug desipramine (DMI) as a direct ligand at the alpha(2A) adrenergic receptor (AR) without itself driving heterotrimeric G protein/downstream effector activation [5].	Desipramine	62-73	adrenoceptor alpha 2A	Homo sapiens	106-135	
22405824-2	2012	We have recently identified the tricyclic antidepressant drug desipramine (DMI) as a direct ligand at the alpha(2A) adrenergic receptor (AR) without itself driving heterotrimeric G protein/downstream effector activation [5].	Desipramine	75-78	adrenoceptor alpha 2A	Homo sapiens	106-135	
21859713-4	2011	In the present study, we have characterized the direct interaction between DMI and the alpha(2A)-adrenergic receptor (alpha(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression.	Desipramine	75-78	adrenoceptor alpha 2A	Homo sapiens	87-116	
21859713-4	2011	In the present study, we have characterized the direct interaction between DMI and the alpha(2A)-adrenergic receptor (alpha(2A)AR), a key regulator of noradrenergic neurotransmission with altered expression and function in depression.	Desipramine	75-78	adrenoceptor alpha 2A	Homo sapiens	118-129	
21859713-5	2011	DMI alone was found to be sufficient to drive receptor internalization acutely and a robust down-regulation of alpha(2A)AR expression and signaling following prolonged stimulation in vitro.	Desipramine	0-3	adrenoceptor alpha 2A	Homo sapiens	111-122	
21859713-8	2011	Prolonged in vivo administration of DMI resulted in significant down-regulation of synaptic alpha(2A)AR expression, a response that was lost in arrestin3-null animals.	Desipramine	36-39	adrenoceptor alpha 2A	Homo sapiens	92-103