PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9723120-14	1998	Since chronic desipramine, and not fluoxetine, is able to increase hippocampal glucocorticoid receptor (GR) expression, interactions of GR with CREB and SP1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region.	Desipramine	14-25	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	79-102	
10520140-4	1999	The time course of the effects of the tricyclic antidepressants desipramine and amitriptyline on GR binding, as assessed by [3H]dexamethasone binding using RU 28362, a specific agonist for GR, showed a biphasic mode of stimulation: desipramine significantly increased the GR binding with 2-day exposure by 36% over that in controls and by 99% and 60% with 10- and 14-day exposures, respectively.	Desipramine	64-75	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	97-99	
10520140-7	1999	Northern blot analysis demonstrated that the GR mRNA level was significantly increased by 14-day treatment with desipramine (+142% over control), amitriptyline (+108%), mianserin (+124%), paroxetine (+42%) and sulpiride (+92%), but not with haloperidol.	Desipramine	112-123	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	45-47	
10520140-8	1999	Immunocytochemistry for GR revealed that 2- or 14-day treatment with desipramine significantly increased the number of GR-positive cells with dominant immunoreactivity in the nuclei of granule cell-like neurones or in perikarya of pyramidal cell- and granule cell-like neurones.	Desipramine	69-80	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	24-26	
10520140-8	1999	Immunocytochemistry for GR revealed that 2- or 14-day treatment with desipramine significantly increased the number of GR-positive cells with dominant immunoreactivity in the nuclei of granule cell-like neurones or in perikarya of pyramidal cell- and granule cell-like neurones.	Desipramine	69-80	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	119-121	
9723120-14	1998	Since chronic desipramine, and not fluoxetine, is able to increase hippocampal glucocorticoid receptor (GR) expression, interactions of GR with CREB and SP1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region.	Desipramine	14-25	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	104-106	
1811246-6	1991	We conclude that desipramine, imipramine, ketanserin and lithium can modulate GR mRNA in regions of rat brain involved in the control of the HPA axis and may have a common mechanism of action at the level of the GR gene.	Desipramine	17-28	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	212-214	
9503270-3	1997	DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (-)-oxaprotiline did not alter hippocampal levels of GR mRNA.	Desipramine	0-3	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	65-88	
9503270-3	1997	DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (-)-oxaprotiline did not alter hippocampal levels of GR mRNA.	Desipramine	0-3	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	90-92	
9503270-3	1997	DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (-)-oxaprotiline did not alter hippocampal levels of GR mRNA.	Desipramine	0-3	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	228-230	
1811246-2	1991	Northern blot analysis of Type II GR mRNA showed that treatment of male rats with either desipramine or imipramine increased hypothalamic and hippocampal GR mRNA levels.	Desipramine	89-100	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	34-36	
1811246-2	1991	Northern blot analysis of Type II GR mRNA showed that treatment of male rats with either desipramine or imipramine increased hypothalamic and hippocampal GR mRNA levels.	Desipramine	89-100	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	154-156	
1811246-6	1991	We conclude that desipramine, imipramine, ketanserin and lithium can modulate GR mRNA in regions of rat brain involved in the control of the HPA axis and may have a common mechanism of action at the level of the GR gene.	Desipramine	17-28	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80