PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25771452-6	2015	MMC and MDMA both induced concentration-dependently [(3)H]1-methyl-4-phenylpyridinium-release from NET-, DAT or SERT-expressing cells which was clearly transporter-mediated release as demonstrated by the selective inhibitory effects of nmolar to low micromolar concentrations of desipramine, GBR 12909 and fluoxetine, respectively.	Desipramine	279-290	solute carrier family 6 member 4	Homo sapiens	112-116	
9063880-6	1997	It has the same specificity as wild type SERT for the antidepressants paroxetine and desipramine.	Desipramine	85-96	solute carrier family 6 member 4	Homo sapiens	41-45	
33513512-8	2021	For example, IC50 value of desipramine for the zSERT was 1/200 of that for the hSERT.	Desipramine	27-38	solute carrier family 6 member 4	Homo sapiens	79-84	
29414147-5	2018	RESULTS: In SH-SY5Y cells, [3H]-dopamine uptake was inhibited by desipramine (selective NET inhibitor), GBR-12909 (selective DAT inhibitor), and fluoxetine (selective inhibitor of the serotonin transporter, SERT) with IC50 values 37, 537, and 2800nM, respectively.	Desipramine	65-76	solute carrier family 6 member 4	Homo sapiens	207-211	
25873594-5	2015	We exemplify our approach by measuring the kinetics of cocaine, methylphenidate, and desipramine binding to SERT and DAT.	Desipramine	85-96	solute carrier family 6 member 4	Homo sapiens	108-112	
25873594-6	2015	Our analysis revealed that the selectivity of methylphenidate and desipramine for DAT and SERT, respectively, can be accounted for by their rate of association and not by the residence time in their respective binding sites.	Desipramine	66-77	solute carrier family 6 member 4	Homo sapiens	90-94	
31442583-7	2019	CD spectroscopic analysis of protein stability allowed identifying CHS and POPX as stabilizing components, which increased hSERT thermostability by 7  C. The kinetic dissociation constant KD of 2.8 muM (+-0.05) for of the inhibitor Desipramine was determined with a ka of 10,848 M - 1 s-1 (+-220) and a kd of 0.03 s-1 (+-4.7 x 10-5).	Desipramine	232-243	solute carrier family 6 member 4	Homo sapiens	123-128	
18815045-7	2008	Desipramine and fluoxetine, specific inhibitors of NET and SERT, respectively, both enhanced the inhibitory effects of propofol but reduced the inhibitory effects of ketamine on NET and SERT functions.	Desipramine	0-11	solute carrier family 6 member 4	Homo sapiens	59-63	
18815045-7	2008	Desipramine and fluoxetine, specific inhibitors of NET and SERT, respectively, both enhanced the inhibitory effects of propofol but reduced the inhibitory effects of ketamine on NET and SERT functions.	Desipramine	0-11	solute carrier family 6 member 4	Homo sapiens	186-190	
18266934-5	2008	drSERT has a higher affinity towards compounds of the imipramine class, desipramine in particular, exhibiting a 35-fold increased affinity compared to hSERT.	Desipramine	72-83	solute carrier family 6 member 4	Homo sapiens	151-156	
21180171-6	2005	Norepinephrine and dopamine could not induce the transporter current while the 5-HT induced current could be specifically inhibited by 5-HTT blocker, desipramine.	Desipramine	150-161	solute carrier family 6 member 4	Homo sapiens	135-140	
12849931-4	2003	Under the conditions of the assays, [(3)H]paroxetine binding in the LC was specific for the SERT, based on the rank order of affinity of compounds for inhibiting [(3)H]paroxetine binding in the LC, i.e. citalopram > imipramine > desipramine > mazindol.	Desipramine	235-246	solute carrier family 6 member 4	Homo sapiens	92-96	
17690258-3	2007	We determined the crystal structure at 2.9 angstroms of the bacterial leucine transporter (LeuT), a homolog of SERT, NET, and DAT, in complex with leucine and the antidepressant desipramine.	Desipramine	178-189	solute carrier family 6 member 4	Homo sapiens	111-115	
17690258-7	2007	Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters.	Desipramine	69-80	solute carrier family 6 member 4	Homo sapiens	33-37	
12657510-5	2003	The SERT inhibitors desipramine and fluoxetine also inhibited (3)H-MPP(+) specific uptake (with IC(50)s of 189 and 0.92 microM, respectively).	Desipramine	20-31	solute carrier family 6 member 4	Homo sapiens	4-8