PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10424850-0 1999 Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells. Desipramine 0-11 solute carrier family 6 member 2 Homo sapiens 58-84 17979223-5 2007 The NET blocker desipramine reduced the uptake of [ (131)I] 12a only to a small extent, further suggesting a limited role of NET in its binding and accumulation. Desipramine 16-27 solute carrier family 6 member 2 Homo sapiens 4-7 16330572-11 2005 11C-mHED accumulation could be inhibited by desipramine, a potent inhibitor of hNET. Desipramine 44-55 solute carrier family 6 member 2 Homo sapiens 79-83 12837768-0 2003 chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. Desipramine 40-51 solute carrier family 6 member 2 Homo sapiens 91-117 14499328-5 2003 Pretreatment with the NET ligand, desipramine, decreased the specific binding of (S,S)-[(11)C]MeNER. Desipramine 34-45 solute carrier family 6 member 2 Homo sapiens 22-25 11082428-3 2000 We previously described down-regulation of the NET in cultured cells after continuous exposure to the tricyclic antidepressant desipramine. Desipramine 127-138 solute carrier family 6 member 2 Homo sapiens 47-50 12499385-7 2003 We show that ASP(+) (4-(4-(dimethylamino)styrl)-N-methylpyridinium) has micromolar potency for the human norepinephrine transporter, that ASP(+) accumulation is Na(+)-, Cl(-)-, cocaine-, and desipramine-sensitive and temperature-dependent, and that ASP(+) competes with norepinephrine uptake. Desipramine 191-202 solute carrier family 6 member 2 Homo sapiens 105-131 12070759-0 2002 Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs. Desipramine 37-48 solute carrier family 6 member 2 Homo sapiens 70-95 12070759-6 2002 These compounds as well as methamphetamine, methcathinone, and desipramine also protected the hNET from NEM inactivation of [(3)H]desipramine binding. Desipramine 63-74 solute carrier family 6 member 2 Homo sapiens 94-98 12070759-6 2002 These compounds as well as methamphetamine, methcathinone, and desipramine also protected the hNET from NEM inactivation of [(3)H]desipramine binding. Desipramine 130-141 solute carrier family 6 member 2 Homo sapiens 94-98 10424850-1 1999 The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. Desipramine 19-30 solute carrier family 6 member 2 Homo sapiens 98-134 10424850-1 1999 The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. Desipramine 19-30 solute carrier family 6 member 2 Homo sapiens 136-139 10424850-3 1999 In this study, we treated SK-N-SHSY5Y cells with 100 nM desipramine for 24 or 72 h, and measured 3H-nisoxetine binding (as an estimate of NETs) and NET mRNA by quantitative reverse transcription polymerase chain reaction. Desipramine 56-67 solute carrier family 6 member 2 Homo sapiens 138-141 10424850-6 1999 We conclude that decreased NET synthesis may contribute to the chronic, but not acute, effect of desipramine to downregulate the NET. Desipramine 97-108 solute carrier family 6 member 2 Homo sapiens 27-30 10424850-6 1999 We conclude that decreased NET synthesis may contribute to the chronic, but not acute, effect of desipramine to downregulate the NET. Desipramine 97-108 solute carrier family 6 member 2 Homo sapiens 129-132 9523572-10 1998 The present findings imply that down-regulation of the hNET in 293-hNET cells induced by desipramine results from a selective reduction in hNET protein levels, presumably a consequence of either a reduction in the translation of hNET mRNA or from an enhanced degradation of hNET protein. Desipramine 89-100 solute carrier family 6 member 2 Homo sapiens 55-59 9523572-0 1998 Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. Desipramine 92-103 solute carrier family 6 member 2 Homo sapiens 29-55 9523572-0 1998 Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. Desipramine 92-103 solute carrier family 6 member 2 Homo sapiens 70-74 9523572-1 1998 The effects of continuous exposure of cultured cells expressing the human norepinephrine transporter (hNET) to the hNET inhibitor desipramine on hNET expression and function were studied. Desipramine 130-141 solute carrier family 6 member 2 Homo sapiens 115-119 9523572-1 1998 The effects of continuous exposure of cultured cells expressing the human norepinephrine transporter (hNET) to the hNET inhibitor desipramine on hNET expression and function were studied. Desipramine 130-141 solute carrier family 6 member 2 Homo sapiens 115-119 9523572-2 1998 Exposure of HEK-293 cells transfected stably with the hNET cDNA (293-hNET cells) to desipramine for 3 days reduced the specific binding of [3H]nisoxetine in membrane homogenates in a concentration-dependent manner. Desipramine 84-95 solute carrier family 6 member 2 Homo sapiens 54-58 9523572-2 1998 Exposure of HEK-293 cells transfected stably with the hNET cDNA (293-hNET cells) to desipramine for 3 days reduced the specific binding of [3H]nisoxetine in membrane homogenates in a concentration-dependent manner. Desipramine 84-95 solute carrier family 6 member 2 Homo sapiens 69-73 9523572-3 1998 The magnitude of the reductions in [3H]nisoxetine binding to hNET was dependent on the length of time of the exposure to desipramine, reaching 77% after a 21-day exposure. Desipramine 121-132 solute carrier family 6 member 2 Homo sapiens 61-65 9523572-6 1998 Similar to binding, hNET protein levels returned to control levels 72 h after cessation of desipramine exposure. Desipramine 91-102 solute carrier family 6 member 2 Homo sapiens 20-24 9523572-7 1998 Northern blotting indicated that exposure of 293-hNET cells to desipramine did not significantly alter hNET mRNA levels. Desipramine 63-74 solute carrier family 6 member 2 Homo sapiens 49-53 9523572-8 1998 Uptake of [3H]norepinephrine by 293-hNET cells was markedly reduced after a 3-day exposure to desipramine. Desipramine 94-105 solute carrier family 6 member 2 Homo sapiens 36-40 9523572-10 1998 The present findings imply that down-regulation of the hNET in 293-hNET cells induced by desipramine results from a selective reduction in hNET protein levels, presumably a consequence of either a reduction in the translation of hNET mRNA or from an enhanced degradation of hNET protein. Desipramine 89-100 solute carrier family 6 member 2 Homo sapiens 67-71 9523572-10 1998 The present findings imply that down-regulation of the hNET in 293-hNET cells induced by desipramine results from a selective reduction in hNET protein levels, presumably a consequence of either a reduction in the translation of hNET mRNA or from an enhanced degradation of hNET protein. Desipramine 89-100 solute carrier family 6 member 2 Homo sapiens 67-71 9523572-10 1998 The present findings imply that down-regulation of the hNET in 293-hNET cells induced by desipramine results from a selective reduction in hNET protein levels, presumably a consequence of either a reduction in the translation of hNET mRNA or from an enhanced degradation of hNET protein. Desipramine 89-100 solute carrier family 6 member 2 Homo sapiens 67-71 9523572-10 1998 The present findings imply that down-regulation of the hNET in 293-hNET cells induced by desipramine results from a selective reduction in hNET protein levels, presumably a consequence of either a reduction in the translation of hNET mRNA or from an enhanced degradation of hNET protein. Desipramine 89-100 solute carrier family 6 member 2 Homo sapiens 67-71 8218295-9 1993 The binding was most potently inhibited by the ligands of the norepinephrine transporter (desipramine and nomifensine). Desipramine 90-101 solute carrier family 6 member 2 Homo sapiens 62-88 8710929-6 1996 These events are stimulated by NE and by guanethidine, an hNET substrate, and they are blocked by cocaine and the antidepressant desipramine. Desipramine 129-140 solute carrier family 6 member 2 Homo sapiens 58-62 8667208-6 1996 Desipramine blocked the toxicity of MPP+ toward the noradrenaline transporter, but not the dopamine transporter expressing cells. Desipramine 0-11 solute carrier family 6 member 2 Homo sapiens 52-77 9428594-0 1997 Synthesis of 11C-labeled desipramine and its metabolite 2-hydroxydesipramine: potential radiotracers for PET studies of the norepinephrine transporter. Desipramine 25-36 solute carrier family 6 member 2 Homo sapiens 124-150 9428594-5 1997 [11C]DMI and [11C]HDMI have potential utility as PET radiotracers for the norepinephrine transporter. Desipramine 5-8 solute carrier family 6 member 2 Homo sapiens 74-100 8374761-0 1993 Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment. Desipramine 98-109 solute carrier family 6 member 2 Homo sapiens 0-26 8374761-1 1993 In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Desipramine 162-173 solute carrier family 6 member 2 Homo sapiens 30-56 8374761-1 1993 In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Desipramine 162-173 solute carrier family 6 member 2 Homo sapiens 58-61 8374761-1 1993 In situ hybridization for the norepinephrine transporter (NET) mRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Desipramine 175-178 solute carrier family 6 member 2 Homo sapiens 58-61 8374761-2 1993 Following short-term and long-term DMI treatment, a significant (P < 0.05) increase in hybridization of 35S-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. Desipramine 35-38 solute carrier family 6 member 2 Homo sapiens 139-142 8315492-6 1993 MIBG uptake in hNET transfected cells is inhibited by 3 x 10(-6) M norepinephrine (87% inhibition) and by hNET transport inhibitors: 10(-7) M desipramine (94% inhibition) and 10(-7) M mazindol (97% inhibition). Desipramine 142-153 solute carrier family 6 member 2 Homo sapiens 15-19 8315492-6 1993 MIBG uptake in hNET transfected cells is inhibited by 3 x 10(-6) M norepinephrine (87% inhibition) and by hNET transport inhibitors: 10(-7) M desipramine (94% inhibition) and 10(-7) M mazindol (97% inhibition). Desipramine 142-153 solute carrier family 6 member 2 Homo sapiens 106-110 32642907-12 2020 In contrast, treatment with desipramine, a NET selective inhibitor, resulted in profoundly decreased xenograft [125I]MIBG levels (p < 0.0001). Desipramine 28-39 solute carrier family 6 member 2 Homo sapiens 43-46 27654664-12 2017 RESULTS: We show dose-dependent inhibition of [125 I]MIBG uptake by dexmedetomidine, but at several logs lower potency than the known NET inhibitor desipramine. Desipramine 148-159 solute carrier family 6 member 2 Homo sapiens 134-137