PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30326559-11 2018 Since we were also able to show that the functional inhibitor of SMPD1, desipramine, ameliorates downregulation of CYP mRNA expression and activities in the acute phase of sepsis in wild-type mice, SMPD1 might be an interesting pharmacological target, which should be further investigated. Desipramine 72-83 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 115-118