PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25873594-5 2015 We exemplify our approach by measuring the kinetics of cocaine, methylphenidate, and desipramine binding to SERT and DAT. Desipramine 85-96 solute carrier family 6 member 3 Homo sapiens 117-120 2529959-4 1989 Analyses of the differences between GMI and DMI indicated that rapid forgetting was more apparent for DAT than for HD patients in the early stages of these disorders. Desipramine 44-47 solute carrier family 6 member 3 Homo sapiens 102-105 25873594-6 2015 Our analysis revealed that the selectivity of methylphenidate and desipramine for DAT and SERT, respectively, can be accounted for by their rate of association and not by the residence time in their respective binding sites. Desipramine 66-77 solute carrier family 6 member 3 Homo sapiens 82-85 17690258-3 2007 We determined the crystal structure at 2.9 angstroms of the bacterial leucine transporter (LeuT), a homolog of SERT, NET, and DAT, in complex with leucine and the antidepressant desipramine. Desipramine 178-189 solute carrier family 6 member 3 Homo sapiens 126-129 17690258-7 2007 Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters. Desipramine 69-80 solute carrier family 6 member 3 Homo sapiens 42-45 8848002-5 1995 In contrast, all chimeras containing dopamine transporter sequences from this region resemble the dopamine transporter, which demonstrates higher affinity for psychomotor stimulants compared with antidepressants (e.g., Ki = 391 +/- 39 nM cocaine compared with 9365 +/- 1260 nM desipramine). Desipramine 277-288 solute carrier family 6 member 3 Homo sapiens 37-57 8848002-5 1995 In contrast, all chimeras containing dopamine transporter sequences from this region resemble the dopamine transporter, which demonstrates higher affinity for psychomotor stimulants compared with antidepressants (e.g., Ki = 391 +/- 39 nM cocaine compared with 9365 +/- 1260 nM desipramine). Desipramine 277-288 solute carrier family 6 member 3 Homo sapiens 98-118 8848002-6 1995 A region including transmembrane domains 1-3 of the norepinephrine transporter also contributes to the interaction of desipramine and nisoxetine, whereas the analogous region of the dopamine transporter influences the affinity for piperazine derivatives (e.g., GBR12909 and LR1111) that are selective for the dopamine transporter. Desipramine 118-129 solute carrier family 6 member 3 Homo sapiens 309-329