PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20211602-0	2010	Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.	Desipramine	86-97	ETS transcription factor ERG	Homo sapiens	47-51	
21832094-3	2011	Importantly, desipramine belongs to a group of tricyclic antidepressant compounds that can simultaneously block hERG and inhibit its surface expression.	Desipramine	13-24	ETS transcription factor ERG	Homo sapiens	112-116	
21832094-5	2011	Here, we have studied in detail how desipramine inhibits hERG surface expression.	Desipramine	36-47	ETS transcription factor ERG	Homo sapiens	57-61	
21832094-6	2011	We find a previously unrecognized combination of two entirely different mechanisms; desipramine increases hERG endocytosis and degradation as a consequence of drug-induced channel ubiquitination and simultaneously inhibits hERG forward trafficking from the endoplasmic reticulum.	Desipramine	84-95	ETS transcription factor ERG	Homo sapiens	106-110	
21832094-6	2011	We find a previously unrecognized combination of two entirely different mechanisms; desipramine increases hERG endocytosis and degradation as a consequence of drug-induced channel ubiquitination and simultaneously inhibits hERG forward trafficking from the endoplasmic reticulum.	Desipramine	84-95	ETS transcription factor ERG	Homo sapiens	223-227	
21120454-0	2011	hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.	Desipramine	70-81	ETS transcription factor ERG	Homo sapiens	0-4	
21120454-8	2011	We found that desipramine reduced hERG currents by binding to a receptor site inside the channel pore.	Desipramine	14-25	ETS transcription factor ERG	Homo sapiens	34-38	
21120454-12	2011	Finally, desipramine triggered apoptosis in cells expressing hERG channels.	Desipramine	9-20	ETS transcription factor ERG	Homo sapiens	61-65	
21120454-13	2011	Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis.	Desipramine	0-11	ETS transcription factor ERG	Homo sapiens	72-76	
21120454-13	2011	Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis.	Desipramine	0-11	ETS transcription factor ERG	Homo sapiens	115-119	
21120454-13	2011	Desipramine exerts at least four different cellular effects: (1) direct hERG channel block, (2) acute reduction of hERG surface expression, (3) chronic disruption of hERG trafficking, and (4) induction of apoptosis.	Desipramine	0-11	ETS transcription factor ERG	Homo sapiens	115-119	
20211602-2	2010	Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of desipramine on hERG channels to determine the electrophysiological basis for its pro-arrhythmic potential.	Desipramine	164-175	ETS transcription factor ERG	Homo sapiens	179-183	
20211602-3	2010	We examined the effects of desipramine on the hERG channels expressed in Xenopus oocytes using two-microelectrode voltage-clamp techniques.	Desipramine	27-38	ETS transcription factor ERG	Homo sapiens	46-50	
20211602-4	2010	Desipramine-induced concentration-dependent decreases in the current amplitude at the end of the voltage steps and hERG tail currents.	Desipramine	0-11	ETS transcription factor ERG	Homo sapiens	115-119	
20211602-5	2010	The IC(50) for desipramine needed to block the hERG current in Xenopus oocytes decreased progressively relative to the degree of depolarization.	Desipramine	15-26	ETS transcription factor ERG	Homo sapiens	47-51	
20211602-7	2010	The S6 domain mutations, Tyr-652 located in the S6 domain of the hERG channel reduced the potency of the channel block by desipramine more than a mutation of Phe-656 in the same region.	Desipramine	122-133	ETS transcription factor ERG	Homo sapiens	65-69	
20211602-8	2010	These results suggest that desipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of desipramine.	Desipramine	27-38	ETS transcription factor ERG	Homo sapiens	59-63	
20211602-8	2010	These results suggest that desipramine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of desipramine.	Desipramine	180-191	ETS transcription factor ERG	Homo sapiens	59-63