PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34935149-0 2022 Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model. Cuprizone 137-146 colony stimulating factor 1 receptor Mus musculus 0-36 34935149-6 2022 Therefore, our goal was to evaluate the effects of a reduction in microglial activation through orally administered brain-penetrant colony-stimulating factor-1 receptor (CSF-1R) inhibitor BLZ945 (BLZ) on neurodegeneration and its correlation with demyelination, astroglial activation and behavior in a chronic CPZ-induced demyelination model. Cuprizone 310-313 colony stimulating factor 1 receptor Mus musculus 132-168 34935149-6 2022 Therefore, our goal was to evaluate the effects of a reduction in microglial activation through orally administered brain-penetrant colony-stimulating factor-1 receptor (CSF-1R) inhibitor BLZ945 (BLZ) on neurodegeneration and its correlation with demyelination, astroglial activation and behavior in a chronic CPZ-induced demyelination model. Cuprizone 310-313 colony stimulating factor 1 receptor Mus musculus 170-176 34274854-0 2021 Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model. Cuprizone 77-86 colony stimulating factor 1 receptor Mus musculus 10-15 32082318-5 2020 We found that after 5 weeks of cuprizone diet that CSF1R suppression caused a significant impairment of microglia function. Cuprizone 31-40 colony stimulating factor 1 receptor Mus musculus 51-56 29448957-11 2018 Taken together, our data suggest that a short-term therapeutic inhibition of the CSF-1 receptor pathway by BLZ945 in the murine cuprizone model enhances central remyelination by modulating neuroinflammation. Cuprizone 128-137 colony stimulating factor 1 receptor Mus musculus 81-95