PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18207576-0	2008	TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model.	Cuprizone	79-88	tumor necrosis factor	Mus musculus	0-3	
18661234-3	2008	Cuprizone-induced demyelination was accompanied by increased expression of inflammatory cytokines, TNFalpha and IL-1beta, anti-inflammatory cytokines TGFbeta, IL-10 and increased levels of chemokines, CCL2, CCL5, and CXCL10, produced by resident microglia and astrocytes.	Cuprizone	0-9	tumor necrosis factor	Mus musculus	99-107	
11600888-1	2001	Here we used mice lacking tumor necrosis factor-alpha (TNF alpha) and its associated receptors to study a model of demyelination and remyelination in which these events could be carefully controlled using a toxin, cuprizone.	Cuprizone	214-223	tumor necrosis factor	Mus musculus	26-53	
15382206-3	2005	Our laboratory has verified a role for TNFalpha in the exacerbation of demyelination but, more importantly, has demonstrated a novel role for TNFalpha in reparative remyelination in a cuprizone-induced demyelination model.	Cuprizone	184-193	tumor necrosis factor	Mus musculus	142-150	
11600888-1	2001	Here we used mice lacking tumor necrosis factor-alpha (TNF alpha) and its associated receptors to study a model of demyelination and remyelination in which these events could be carefully controlled using a toxin, cuprizone.	Cuprizone	214-223	tumor necrosis factor	Mus musculus	55-64	
28923306-7	2017	Baicalein treatment also inhibited the cuprizone-induced increase in Iba1-positive microglia (P<0.001), GFAP-positive astrocytes (P<0.001), and the gene expressions of CD11b (P<0.01), GFAP (P<0.05), TNFalpha (P<0.05), IL-1beta (P<0.05), and iNOS (p<0.01).	Cuprizone	39-48	tumor necrosis factor	Mus musculus	211-219	
34618622-6	2021	Tofacitinib also showed anti-inflammatory effect by alleviating the cuprizone-induced increase in the central levels of interferon-gamma (IFN-gamma), interleukin (IL)-6, IL-1beta, and tumor necrosis alpha (TNF-alpha).	Cuprizone	68-77	tumor necrosis factor	Mus musculus	206-215	
26404052-11	2015	CPZ induced an increase in the expression of GFAP, IL-1beta TNF-alpha, total NFkB and inactive AMPK, and prompt microglia activation.	Cuprizone	0-3	tumor necrosis factor	Mus musculus	60-69	
23970812-4	2013	Cuprizone increased GFAP, Iba-1, TNF- alpha , COX-2, IL-1 beta , and IFN- gamma expression, decreased expression of glutathione S-transferase pi (GSTpi), and damaged myelin in iNOS(-/-) mice.	Cuprizone	0-9	tumor necrosis factor	Mus musculus	33-43	
25224839-4	2014	Administration of the FP receptor antagonist AL-8810 attenuated cuprizone-induced demyelination, glial activation, and TNFalpha expression in the corpus callosum, and also improved the motor function.	Cuprizone	64-73	tumor necrosis factor	Mus musculus	119-127	
24930935-13	2014	Compared to controls, we observed a vast reduction of RNA levels for proinflammatory cytokines and chemokines like Ccl2, Cxcl10, Tnf and Il6 within the CNS of cuprizone-treated mice.	Cuprizone	159-168	tumor necrosis factor	Mus musculus	129-132