PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35060065-6 2022 Furthermore, Ser133-phosphorylated cAMP response element-binding protein (pCREB)-positive nuclei and brain-derived neurotrophic factor (BDNF) protein levels were significantly reduced in young adult mice following cuprizone treatment in young adult, although again not in the aged mice. Cuprizone 214-223 brain derived neurotrophic factor Mus musculus 101-134 34274431-6 2021 Furthermore, CPZ feeding decreased the number of BDNF+ cells in the brain cortex and hippocampus regions, but increased microglia in the brain corpus callosum, cortex and caudate putamen, and astrocytes in the corpus callosum regions of mice. Cuprizone 13-16 brain derived neurotrophic factor Mus musculus 49-53 34274431-7 2021 Treatment with ICA significantly mitigated or abrogated the toxic demyelination of CPZ by preserving MBP and BDNF proteins and modulating the numbers of Ols, OPCs, microglia and astrocytes in the brain of mice. Cuprizone 83-86 brain derived neurotrophic factor Mus musculus 109-113 33811383-0 2021 CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5. Cuprizone 38-47 brain derived neurotrophic factor Mus musculus 14-18 33811383-3 2021 Our previous work indicated that enhancing astrocyte-derived BDNF via injection of a general agonist of Group I/II metabotropic glutamate receptors (mGluRs) into the lesion increased myelin proteins in the cuprizone model of demyelination after 4 hr. Cuprizone 206-215 brain derived neurotrophic factor Mus musculus 61-65 35060065-6 2022 Furthermore, Ser133-phosphorylated cAMP response element-binding protein (pCREB)-positive nuclei and brain-derived neurotrophic factor (BDNF) protein levels were significantly reduced in young adult mice following cuprizone treatment in young adult, although again not in the aged mice. Cuprizone 214-223 brain derived neurotrophic factor Mus musculus 136-140 33709265-10 2021 Telmisartan or nifedipine attenuated cuprizone-induced oxidative stress and apoptosis by decreasing brain malondialdehyde and caspase-3 along with restoring reduced glutathione and brain-derived neurotrophic factor levels. Cuprizone 37-46 brain derived neurotrophic factor Mus musculus 181-214 35353146-0 2022 DHF-7 ameliorates behavioral disorders and white matter lesions by regulating BDNF and Fyn in a mouse model of schizophrenia induced by cuprizone and MK-801. Cuprizone 136-145 brain derived neurotrophic factor Mus musculus 78-82 32638202-6 2020 In addition, CR regimen significantly increased the transcript expression levels of BDNF, Sox2, and Sirt1 in the corpus callosum of CPZ mice, while decreasing the p53 levels. Cuprizone 132-135 brain derived neurotrophic factor Mus musculus 84-88 25586993-2 2015 Roles in vivo are less well understood; however, increases in numbers of OPCs are restricted in BDNF+/- mice following cuprizone-elicited demyelination. Cuprizone 119-128 brain derived neurotrophic factor Mus musculus 96-100 32927995-1 2020 The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. Cuprizone 177-186 brain derived neurotrophic factor Mus musculus 14-47 32927995-1 2020 The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. Cuprizone 177-186 brain derived neurotrophic factor Mus musculus 49-53 32927995-2 2020 In particular, BDNF+/- mice exhibit greater losses in myelin protein levels compared to wild-type mice after cuprizone. Cuprizone 109-118 brain derived neurotrophic factor Mus musculus 15-19 29775986-4 2018 Animals that received cuprizone showed poorer motor function, lower expression of BDNF, GDNF, NGF, and fewer oligodendrocytes in the hippocampus compared to the control animals. Cuprizone 22-31 brain derived neurotrophic factor Mus musculus 82-86 31429533-0 2019 Melatonin ameliorates cuprizone-induced reduction of hippocampal neurogenesis, brain-derived neurotrophic factor, and phosphorylation of cyclic AMP response element-binding protein in the mouse dentate gyrus. Cuprizone 22-31 brain derived neurotrophic factor Mus musculus 79-112 31429533-7 2019 Moreover, cuprizone administration decreased glucose utilization (GLUT3-positive cells) and cell transcription (pCREB-positive cells and BDNF protein expression) in the dentate gyrus. Cuprizone 10-19 brain derived neurotrophic factor Mus musculus 137-141 31429533-9 2019 CONCLUSION: The results of the study suggest that cuprizone treatment disrupts hippocampal neurogenesis in the dentate gyrus by reducing BDNF levels and decreasing the phosphorylation of CREB. Cuprizone 50-59 brain derived neurotrophic factor Mus musculus 137-141 25586993-11 2015 In contrast, when mice were challenged by cuprizone for 4 or 5 weeks, increases in OPCs observed in BDNF+/+ mice were reduced in the BDNF+/- mice. Cuprizone 42-51 brain derived neurotrophic factor Mus musculus 100-104 25586993-11 2015 In contrast, when mice were challenged by cuprizone for 4 or 5 weeks, increases in OPCs observed in BDNF+/+ mice were reduced in the BDNF+/- mice. Cuprizone 42-51 brain derived neurotrophic factor Mus musculus 133-137 21976503-0 2011 Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion. Cuprizone 64-73 brain derived neurotrophic factor Mus musculus 10-14 24920623-0 2014 Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination. Cuprizone 63-72 brain derived neurotrophic factor Mus musculus 18-22 24920623-5 2014 Following cuprizone-elicited demyelination in mice, astrocytes contain BDNF and increase levels of metabotropic receptors. Cuprizone 10-19 brain derived neurotrophic factor Mus musculus 71-75 21976503-4 2011 BDNF protein levels were reduced after cuprizone treatment, suggesting that the demyelinating lesion itself elicits a decrease in BDNF. Cuprizone 39-48 brain derived neurotrophic factor Mus musculus 0-4 21976503-4 2011 BDNF protein levels were reduced after cuprizone treatment, suggesting that the demyelinating lesion itself elicits a decrease in BDNF. Cuprizone 39-48 brain derived neurotrophic factor Mus musculus 130-134