PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33709265-13	2021	In conclusion, the current study provides evidence for the protective effect of telmisartan and nifedipine in cuprizone-induced demyelination and behavioral dysfunction in mice possibly by modulating NF-kappaB and Nrf2 signaling pathways.	Cuprizone	110-119	nuclear factor, erythroid derived 2, like 2	Mus musculus	214-218	
34416238-12	2021	In addition, CPZ intake significantly decreased the cerebral cortex levels of p-Nrf2 (P < 0.001) and increased the levels of p-IKB (P < 0.001) and, these changes were normalized in the TF groups.	Cuprizone	13-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84	
34416238-14	2021	TF can to reduce the harmful effects of CPZ by reducing the demyelination and modulating the Nrf2 and NF-kB signaling pathways.	Cuprizone	40-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97	
31529356-4	2020	Here, we use the cuprizone mouse model of MS to induce oxidative stress, selective oligodendrocyte loss, microglia and astrocyte activation as well as axonal damage in both wild type and Nrf2-deficient mice.	Cuprizone	17-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	187-191	
31529356-5	2020	We found increased oligodendrocyte apoptosis and loss, pronounced neuroinflammation and higher levels of axonal damage in cuprizone-fed Nrf2-deficient animals when compared to wild type controls.	Cuprizone	122-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140	
31529356-6	2020	In addition, Nrf2-deficient animals showed a higher susceptibility towards cuprizone within the commissura anterior white matter tract, a structure that is relatively insensitive to cuprizone in wild type animals.	Cuprizone	75-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
31529356-6	2020	In addition, Nrf2-deficient animals showed a higher susceptibility towards cuprizone within the commissura anterior white matter tract, a structure that is relatively insensitive to cuprizone in wild type animals.	Cuprizone	182-191	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17	
31529356-8	2020	Further studies will have to show whether distinct expression patterns of Nrf2 are involved in the variable susceptibility towards cuprizone in the mouse.	Cuprizone	131-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78	
27713953-7	2016	Our data revealed that myricetin may be a potential candidate for mitigating motor defects and demyelination in a cuprizone-induced mouse model via activating the Nrf2 pathway.	Cuprizone	114-123	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167	
27713953-0	2016	Myricetin alleviates cuprizone-induced behavioral dysfunction and demyelination in mice by Nrf2 pathway.	Cuprizone	21-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95