PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31960518-0 2020 Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: An investigation at the protein level. Trichloroacetic Acid 67-70 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 33-37 33649794-7 2021 The analysis of the DEGs identified from RNA-Seq and validated by RT-qPCR revealed that succinate dehydrogenase complex subunit D (SDHD) and isocitrate dehydrogenase 1 (IDH1), which are key enzymes of the TCA cycle that regulate oncometabolite production, may be potential downstream targets of Bcl2l10. Trichloroacetic Acid 205-208 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 141-167 33649794-7 2021 The analysis of the DEGs identified from RNA-Seq and validated by RT-qPCR revealed that succinate dehydrogenase complex subunit D (SDHD) and isocitrate dehydrogenase 1 (IDH1), which are key enzymes of the TCA cycle that regulate oncometabolite production, may be potential downstream targets of Bcl2l10. Trichloroacetic Acid 205-208 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 169-173 31960518-2 2020 In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA cycle are associated with IDH1 mut. Trichloroacetic Acid 109-112 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 139-143 31960518-4 2020 We observed significant changes in the enzyme abundance associated with aerobic glycolysis, glutamate metabolism, and the TCA cycle in IDH1 mut gliomas. Trichloroacetic Acid 122-125 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 135-139 31960518-8 2020 We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas. Trichloroacetic Acid 113-116 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 20-24 31960518-8 2020 We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas. Trichloroacetic Acid 113-116 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 135-139 29312565-6 2017 Of particular significance, miR-144-5p exhibits a high positive correlation with oxoglutaric acid, isocitrate dehydrogenase (IDH) 1 and 2 that involved in the TCA cycle. Trichloroacetic Acid 159-162 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 99-137 29871819-4 2018 Isocitrate dehydrogenase 1 (IDH1), a metabolic enzyme in the TCA cycle, its reaction product is involved in lipid synthesis. Trichloroacetic Acid 61-64 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-26 29871819-4 2018 Isocitrate dehydrogenase 1 (IDH1), a metabolic enzyme in the TCA cycle, its reaction product is involved in lipid synthesis. Trichloroacetic Acid 61-64 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 28-32 29692895-11 2018 Overexpression of mutant IDH1 in a wildtype line did not reproduce the range of metabolic differences observed in lines expressing endogenous mutations, but resulted in depletion of glutamine and TCA cycle intermediates, an increase in DNA damage following radiation, and a rise in intracellular ROS. Trichloroacetic Acid 196-199 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 25-29 29312565-7 2017 Furthermore,we discovered that miR-144-5p regulates TCA cycle metabolism through IDH1 and IDH2. Trichloroacetic Acid 52-55 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 81-85 27380194-5 2016 Additionally, the mutation of isocitrate dehydrogenase (IDH), the enzyme downstream of ACO1 in the TCA cycle, is associated with epigenetic abnormalities secondary to 2-hydroxyglutarate (2-HG) and DNA methylation. Trichloroacetic Acid 99-102 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 30-54 27380194-5 2016 Additionally, the mutation of isocitrate dehydrogenase (IDH), the enzyme downstream of ACO1 in the TCA cycle, is associated with epigenetic abnormalities secondary to 2-hydroxyglutarate (2-HG) and DNA methylation. Trichloroacetic Acid 99-102 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 56-59 27380194-9 2016 Digital PCR further showed that Idh1 and Aco1, enzymes involved in the TCA cycle, were also elevated. Trichloroacetic Acid 71-74 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 32-36 26442042-6 2015 The trend of increment in TCA cycle genes like ATCs, ACo1, and IDH in the combined treatment might support the observed increment in organic acids, GABA shunt, and their derivatives. Trichloroacetic Acid 26-29 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 63-66 26590767-2 2015 IDH occurs in three isoforms, IDH1, located in the cytoplasm, IDH2 located in the mitochondria, and IDH3, which functions as part of the TCA cycle. Trichloroacetic Acid 137-140 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-3 24616559-2 2014 This TCA cycle is regulated by Isocitrate dehydrogenase (IDH) we have earlier cloned, sequenced (HM067707), expressed and characterized this enzyme from S. aureus ATCC12600. Trichloroacetic Acid 5-8 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 57-60 21764377-1 2011 A role for mitochondria in tumor formation is suggested by mutations in enzymes of the TCA cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate hydratase (FH). Trichloroacetic Acid 87-90 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 98-122 21764377-1 2011 A role for mitochondria in tumor formation is suggested by mutations in enzymes of the TCA cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate hydratase (FH). Trichloroacetic Acid 87-90 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 124-127