PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24973766-0	2014	Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway.	torbafylline	34-46	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	135-139	
24973766-5	2014	Torbafylline enhanced protein levels of exchange protein directly activated by cAMP (Epac) both in skeletal muscle of burn rats and in TNFalpha+IFNgamma treated C2C12 myotubes.	torbafylline	0-12	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	85-89	
24973766-6	2014	Pretreatment with a specific antagonist of PI3K or Epac significantly reversed the inhibitory effects of torbafylline on TNFalpha+IFNgamma-induced MAFbx mRNA expression and protein breakdown in C2C12 myotubes.	torbafylline	105-117	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	51-55	
24973766-7	2014	Torbafylline inhibits burn-induced muscle proteolysis by activating multiple pathways through PDE4/cAMP/Epac/PI3K/Akt.	torbafylline	0-12	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	104-108