PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33197826-4 2021 We decided to deepen the following aspects: (i) understanding the role of each histidine in the coordination of metal ions; (ii) comparing the binding affinities for Cu(II), Ni(II) and Zn(II) ions, which are potentially competing metals in vivo; (iii) understanding the Hpn ability of forming ternary and poly-nuclear complexes. cu(ii) 166-172 hepsin Homo sapiens 270-273