PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20622253-4 2010 Here we show that Fe(II/III) and Cu(II) at physiological levels bind to NEIL1 and NEIL2 to alter their secondary structure and strongly inhibit repair of mutagenic 5-hydroxyuracil, a common cytosine oxidation product, both in vitro and in neuroblastoma (SH-SY5Y) cell extract by affecting the base excision and AP lyase activities of NEILs. cu(ii) 33-39 nei like DNA glycosylase 1 Homo sapiens 72-77